Document Detail

Effect of ovine hydatid cyst fluid on the cardiovascular and respiratory systems in sheep.
MedLine Citation:
PMID:  1099969     Owner:  NLM     Status:  MEDLINE    
Rupture of the hydatid cyst in man brings about mild to severe toxic reactions including death. The present study was undertaken to investigate some of the responses resulting from administration of the ovine hydatid fluid to the sheep, which, like man, is an intermediate host of the Echinococcus granulosus. In 50 sodium pentobarbital-anesthetized sheep, the arterial blood pressure (A.B.P.), central venous pressure (C.V.P.), respiration and electrocardiogram were recorded. Intraveonus administration of 5-10 ml hydatid fluid brought about moderate to severe fall in A.B.P. and rapid respiration with or without transient apnea or permanent repiratory cessation in 80 percent of the animals. Fifty percent of the sheep died of circulatory and respiratory failure after the first injection of the hydatid fluid. Boiled hydatid fluid did not lose its potency to evoke the above responses. Pretreatment of the aminals with atropine sulfate, 0,5 mg/kg subcutaneously, did not block the reactions. Administration of the antihistamine chlorpheniramine, 4 mg/kg intravenously, caused partial prevention of the reactions in 6 out of 10 responsive sheep. The cardiovascular and respiratory responses to ovine hydatid fluid may be due to antigen-antibody reactions or some toxic component of the fluid.
M Tabatabai; M H Ismaili; M Sami; R Fardin; R Kadivar
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annales de parasitologie humaine et comparée     Volume:  50     ISSN:  0003-4150     ISO Abbreviation:  Ann Parasitol Hum Comp     Publication Date:    1975 Jan-Feb
Date Detail:
Created Date:  1975-12-04     Completed Date:  1975-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376525     Medline TA:  Ann Parasitol Hum Comp     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  7-15     Citation Subset:  IM    
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MeSH Terms
Antigen-Antibody Reactions
Atropine / administration & dosage
Blood Pressure / drug effects
Cardiovascular Diseases / etiology*
Chlorpheniramine / administration & dosage
Clinical Trials as Topic
Echinococcosis / complications,  veterinary*
Echinococcus / isolation & purification
Evoked Potentials
Heart Rate / drug effects
Positive-Pressure Respiration
Respiration / drug effects
Respiratory Insufficiency / etiology*,  veterinary
Rupture, Spontaneous
Sheep Diseases / parasitology*
Reg. No./Substance:
132-22-9/Chlorpheniramine; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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