Document Detail


Effect of ovine hydatid cyst fluid on the cardiovascular and respiratory systems in sheep.
MedLine Citation:
PMID:  1099969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rupture of the hydatid cyst in man brings about mild to severe toxic reactions including death. The present study was undertaken to investigate some of the responses resulting from administration of the ovine hydatid fluid to the sheep, which, like man, is an intermediate host of the Echinococcus granulosus. In 50 sodium pentobarbital-anesthetized sheep, the arterial blood pressure (A.B.P.), central venous pressure (C.V.P.), respiration and electrocardiogram were recorded. Intraveonus administration of 5-10 ml hydatid fluid brought about moderate to severe fall in A.B.P. and rapid respiration with or without transient apnea or permanent repiratory cessation in 80 percent of the animals. Fifty percent of the sheep died of circulatory and respiratory failure after the first injection of the hydatid fluid. Boiled hydatid fluid did not lose its potency to evoke the above responses. Pretreatment of the aminals with atropine sulfate, 0,5 mg/kg subcutaneously, did not block the reactions. Administration of the antihistamine chlorpheniramine, 4 mg/kg intravenously, caused partial prevention of the reactions in 6 out of 10 responsive sheep. The cardiovascular and respiratory responses to ovine hydatid fluid may be due to antigen-antibody reactions or some toxic component of the fluid.
Authors:
M Tabatabai; M H Ismaili; M Sami; R Fardin; R Kadivar
Related Documents :
3770929 - Controversies in the fluid management of post-traumatic lung disease.
141889 - Mucopolysaccharide osmotic pressure in the measurement of interstitial pressure.
19871899 - Donnan equilibrium and the physical properties of proteins : ii. osmotic pressure.
3763079 - Influence of crystalloid versus colloid infusion on peripartum colloid osmotic pressure...
9797519 - Serum albumin and colloid osmotic pressure in survivors and nonsurvivors of prolonged c...
6802159 - Changes in colloid osmotic pressure with plasma albumin concentration associated with e...
12470149 - Family score as an indicator of genetic risk of primary open-angle glaucoma.
23394099 - Stochastic impulsive pressure calculations for time dependent human hip joint lubrication.
3170439 - Bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annales de parasitologie humaine et comparée     Volume:  50     ISSN:  0003-4150     ISO Abbreviation:  Ann Parasitol Hum Comp     Publication Date:    1975 Jan-Feb
Date Detail:
Created Date:  1975-12-04     Completed Date:  1975-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376525     Medline TA:  Ann Parasitol Hum Comp     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  7-15     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antigen-Antibody Reactions
Atropine / administration & dosage
Blood Pressure / drug effects
Cardiovascular Diseases / etiology*
Cats
Chlorpheniramine / administration & dosage
Clinical Trials as Topic
Dogs
Echinococcosis / complications,  veterinary*
Echinococcus / isolation & purification
Evoked Potentials
Heart Rate / drug effects
Humans
Positive-Pressure Respiration
Respiration / drug effects
Respiratory Insufficiency / etiology*,  veterinary
Rupture, Spontaneous
Sheep
Sheep Diseases / parasitology*
Chemical
Reg. No./Substance:
132-22-9/Chlorpheniramine; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Activation of the complement and properdin systems in rheumatoid arthritis.
Next Document:  Sequential analysis of effectiveness of diazepam, a tranquilizer, on stress in swine (author's trans...