Document Detail


Effect of ovariectomy on response to dietary cholesterol in patas monkeys (Erythrocebus patas).
MedLine Citation:
PMID:  3111879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
From a group of 20 patas monkeys (Erythrocebus patas), four high and four low responders to dietary cholesterol were selected for this study. The monkeys were paired according to their responsiveness to cholesterol, and ovariectomies were carried out on one group of the matched pairs. For the study, the monkeys were fed a Prudent Diet (at 0.1 mg cholesterol/cal) for 5 months preceding the ovariectomy and for 7 months after the ovariectomy followed by a Rich Diet (at 0.4 mg cholesterol/cal) for 7 months. Serum cholesterol, apo B, and apo A-I concentrations and cholesterol distributions were determined. We observed that while the monkeys consumed the Prudent Diet, total serum cholesterol. HDL cholesterol, and apo A-I increased in the ovariectomized group, but not in the control group. When they began consuming the Rich Diet, total serum cholesterol, apo B, and apo A-I concentrations increased in all monkeys, but increased more in the ovariectomized monkeys. The effect of the loss of ovarian function on lipoprotein metabolism is accentuated when the monkeys are fed a Rich Diet designed to be similar to a saturated fat, cholesterol-rich diet consumed by human beings.
Authors:
H N Baker; C R Abee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental and molecular pathology     Volume:  47     ISSN:  0014-4800     ISO Abbreviation:  Exp. Mol. Pathol.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-09-08     Completed Date:  1987-09-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370711     Medline TA:  Exp Mol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  76-89     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoprotein A-I
Apolipoproteins A / blood
Apolipoproteins B / blood
Centrifugation, Density Gradient
Cholesterol / blood
Cholesterol, Dietary / administration & dosage*
Cholesterol, HDL / blood
Erythrocebus patas
Female
Lipoproteins / blood*
Lipoproteins, HDL / analysis,  blood
Lipoproteins, LDL / analysis,  blood
Ovariectomy*
Ovary / metabolism*
Grant Support
ID/Acronym/Agency:
HL 25596/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoproteins A; 0/Apolipoproteins B; 0/Cholesterol, Dietary; 0/Cholesterol, HDL; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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