Document Detail

Effect of ovariectomy in heart failure-prone SHHF/Mcc-facp rats.
MedLine Citation:
PMID:  9843886     Owner:  NLM     Status:  MEDLINE    
The importance of the loss of ovarian function to the progression of hypertension and heart disease in women is controversial. We investigated whether ovariectomy would accelerate development of hypertension, congestive heart failure, and neurohumoral activation in adult spontaneous hypertension heart failure (SHHF) rats, a genetic model of heart failure. Six months after ovariectomy, no significant differences between control and ovariectomized rats were seen in systolic or diastolic blood pressure, left ventricular fractional shortening by echocardiography, or heart weight. Percent V1 myosin isozyme was significantly lower in ovariectomized rats. Northern blot analysis failed to show significant differences between groups in expression of hepatic angiotensinogen, renal renin, or left ventricular atrial or brain natriuretic peptide mRNA. In a second experiment, serial measures of systolic pressure and left ventricular shortening fractions failed to document a significant difference between control and ovariectomized rats as they developed heart failure, although there was a significant decline in shortening fraction in both groups at the age when regular estrous cycling naturally ceases. Survival time was similar between groups. In summary, ovariectomy of adult SHHF rats does not appear to affect the progression of genetically programmed hypertension and heart failure in this model.
L C Sharkey; B J Holycross; S Park; S A McCune; R Hoversland; M J Radin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  275     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-02-01     Completed Date:  1999-02-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1968-76     Citation Subset:  IM    
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA.
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MeSH Terms
Blood Pressure / physiology
Cardiac Output, Low / genetics*,  pathology,  physiopathology
Disease Progression
Genetic Predisposition to Disease*
Hypertension / genetics*,  physiopathology
Myocardium / pathology
Myosins / metabolism
Organ Size
Rats, Inbred Strains / genetics*
Reference Values
Survival Analysis
Ventricular Function, Left / physiology
Grant Support
Reg. No./Substance:

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