Document Detail

Effect of ovarian steroid hormones and the presence of the fetus on oxytocin gene expression in the uterus.
MedLine Citation:
PMID:  7561624     Owner:  NLM     Status:  MEDLINE    
Oxytocin (OT) is a neurohypophysial hormone with potent stimulating activity of the pregnant uterus, but its physiological role in parturition is still unclear. Recently, OT was found to be synthesized in the pregnant uterus, indicating that OT originating from the uterus, not from the posterior pituitary gland, may trigger the onset of labour. In order to define the factors responsible for the induction of uterine OT, the effect of ovarian steroid hormones and conceptus on the induction of OT mRNA in the rat uterus was examined by Northern and dot blot hybridization analysis. OT mRNA in the uterus started to increase on day 14 of pregnancy and showed very high levels at the time of parturition. Uterine OT mRNA was not altered by any steroid treatment, oestradiol-17 beta (0.2 microgram), progesterone (4 mg) or both in combination, for 6 days. The gravid horn of the uterus had 3.6-fold as much OT mRNA as the non-gravid horn on day 21 of pregnancy in hemipregnant rats with one ligated oviduct. The ovarian steroid hormones could not induce accumulation of OT mRNA in the uterus of ovariectomized rats, at least under the conditions used, but the presence of a conceptus may be critical for the very high levels of OT mRNA.
T Higuchi; C X Liu; H Saito; H Negoro; S Matsukawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  146     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-10-25     Completed Date:  1995-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  81-5     Citation Subset:  IM    
Department of Physiology, Kochi Medical School, Japan.
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MeSH Terms
Blotting, Northern
Estradiol / pharmacology
Fetus / physiology*
Gene Expression / drug effects
Gestational Age
Gonadal Steroid Hormones / pharmacology*
In Situ Hybridization
Oxytocin / genetics*
Progesterone / pharmacology
RNA, Messenger / analysis
Rats, Wistar
Uterus / metabolism*
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/RNA, Messenger; 50-28-2/Estradiol; 50-56-6/Oxytocin; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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