Document Detail


Effect of outflow pressure on intestinal lymph flow in unanesthetized sheep.
MedLine Citation:
PMID:  2012238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lymphatic vessels are important in removing excess fluid from the intestines and preventing intestinal edema. In this study we used the relationship between intestinal lymph flow rate (QL) and lymphatic outflow pressure (PO) to analyze the flow from intestinal lymphatics in unanesthetized sheep. We cannulated intestinal lymphatic vessels in six anesthetized sheep. One to 3 days after the surgery, we measured QL as we increased PO in steps. We found no QL decrease until PO greater than 15 cmH2O, but QL decreased significantly for PO greater than 15 cmH2O and was decreased to zero at PO = 34 +/- 13 (SD) cmH2O. In three experiments, we used the pressure pulses generated by the active lymphatic pump to estimate the pump stroke volume and frequency. These data indicate that increases in lymphatic pumping prevented a QL decreased for PO less than 15 cmH2O and the QL decrease for PO greater than 15 cmH2O was associated with lymphatic pump failure. When we increased portal venous pressure from baseline (10.1 +/- 4.1 cmH2O) to 24.3 +/- 6.2 cmH2O, lymph flow increased, but it was much more sensitive to outflow pressure. These results are important because they indicate that the ability of the lymphatics to remove fluid from edematous intestines may be compromised by small increases in lymphatic outflow pressure.
Authors:
R E Drake; J C Gabel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  260     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-09     Completed Date:  1991-05-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R668-71     Citation Subset:  IM    
Affiliation:
Center for Microvascular and Lymphatic Studies, University of Texas Medical School, Houston 77030.
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MeSH Terms
Descriptor/Qualifier:
Animals
Hydrostatic Pressure
Intestines / physiology*
Kinetics
Lymph / physiology*
Sheep
Grant Support
ID/Acronym/Agency:
DK-41859/DK/NIDDK NIH HHS; HL-36635/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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