Document Detail

Effect of ouabain on adrenal potassium balance in sheep.
MedLine Citation:
PMID:  1187705     Owner:  NLM     Status:  MEDLINE    
A previous study revealed that ouabain caused a marked decrease in aldosterone secretion, but the adrenal K status was not clear from those data. The present study investigated the magnitude and time course of change in adrenal K balance when ouabain was administered into the adrenal arterial supply of the in situ adrenal of conscious sheep. Ouabain at an adrenal arterial plasma concentration of approximately 2.4 X 10(-4) M produced a striking negative adrenal K balance within 10 min of beginning the infusion. The adrenal continued to lose K during the 30-min infusion and for 30 min thereafter. The mean total K loss was 42.3 +/- 7.9 muequiv/adrenal (n = 11). Thirty minutes after ending the ouabain infusion, the adrenal began taking up K but had not recovered its normal K complement by 60 min.
E H Blaine; J P Coghlan; D A Denton; K J Hardy; B A Scoggins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  150     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1976-01-16     Completed Date:  1976-01-16     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / drug effects*,  metabolism
Ouabain / pharmacology*
Potassium / blood,  metabolism*
Time Factors
Reg. No./Substance:
630-60-4/Ouabain; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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