Document Detail


Effect of osmolarity on the zero-stress state and mechanical properties of aorta.
MedLine Citation:
PMID:  17573459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some pathological conditions may affect osmolarity, which can impact cell, tissue, and organ volume. The hypothesis of this study is that changes in osmolarity affect the zero-stress state and mechanical properties of the aorta. To test this hypothesis, a segment of mouse abdominal aorta was cannulated in vivo and mechanically distended by perfusion of physiological salt (NaCl) solutions with graded osmolarities from 145 to 562 mosM. The mechanical (circumferential stress, strain, and elastic modulus) and morphological (wall thickness and wall area) parameters in the loaded state were determined. To determine the osmolarity-induced changes of zero-stress state, the opening angle was observed by immersion of the sectors of mouse, rat, and pig thoracic aorta in NaCl solution with different osmolarities. Wall volume and tissue water content of the rings were also recorded at different osmolarities. Our results show that acute aortic swelling due to low osmolarity leads to an increase in wall thickness and area, a change in the stress-strain relationship, and an increase in the elastic modulus (stiffness) in mouse aorta. The opening angle, wall volume, and water content decreased significantly with increase in osmolarity. These findings suggest that acute aortic swelling and shrinking result in immediate mechanical changes in the aorta. Osmotic pressure-induced changes in the zero-stress state may serve to regulate mechanical homeostasis.
Authors:
Xiaomei Guo; Yoram Lanir; Ghassan S Kassab
Related Documents :
18003209 - Assessment of slow-breathing relaxation technique in acute stressful tasks using a mult...
3584149 - Residual stress and strain in aortic segments.
8906519 - Effects of angiotensin converting enzyme inhibitor on renal haemodynamics during mental...
23247119 - Early airway pressure release ventilation prevents ards-a novel preventive approach to ...
2928459 - Hostility and cardiovascular reactivity to stress in women and men.
3448129 - The stress-moderating effects of weeping and humor.
4036999 - Effects of hypoxemic events on breathing, body movements, and heart rate variation: a s...
22389749 - Molecular and pathophysiological features of angiotensinogen: a mini review.
1704979 - Atrial natriuretic factor attenuates sympathetic reflexes during lower body negative pr...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-06-15
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  293     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-09     Completed Date:  2007-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H2328-34     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Surgery, and Cellular and Integrative Physiology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / drug effects*,  metabolism,  pathology,  physiopathology
Edema / metabolism,  pathology*,  physiopathology
Elasticity
Homeostasis
Male
Mice
Mice, Inbred C57BL
Models, Cardiovascular
Osmolar Concentration
Osmotic Pressure
Pressure
Rats
Rats, Wistar
Sodium Chloride / chemistry,  pharmacology*
Stress, Mechanical
Sus scrofa
Water / metabolism
Grant Support
ID/Acronym/Agency:
2 R01 HL-055554-06/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7647-14-5/Sodium Chloride; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differential sympathetic outflow elicited by active muscle in rats.
Next Document:  Early changes in coronary artery wall structure detected by microcomputed tomography in experimental...