Document Detail

Effect of orlistat-assisted weight loss in decreasing coronary heart disease risk in patients with syndrome X.
MedLine Citation:
PMID:  11274935     Owner:  NLM     Status:  MEDLINE    
This study describes the changes in risk factors for coronary heart disease in obese persons with syndrome X after orlistat-assisted weight loss. Data were available for 1,700 patients who completed 52 weeks of weight loss; 128 were defined as having syndrome X by being in the quintile with the highest plasma triglyceride levels (>2.2 mM/L) and the lowest high-density lipoprotein cholesterol (HDL, <1.0 mM/L) concentrations. Initial characteristics of those with syndrome X were similar to the 119 subjects (non-syndrome X) in the lowest quintile of plasma triglyceride (<0.975 mM/L) and highest quintile of HDL cholesterol (>1.5 mM/L). Subjects were placed on a calorie-restricted diet, and randomized to receive orlistat or placebo. Initial values were higher in those with syndrome X for diastolic blood pressure (p = 0.03), plasma insulin (p = 0.0001), triglyceride (p = 0.0001) concentrations, and ratio of low-density lipoprotein cholesterol to HDL cholesterol (p = 0.0001), and were lower for HDL cholesterol (p = 0.001) concentrations. Weight loss was greater in both groups of orlistat-treated patients (p = 0.026); in those with syndrome X, it was associated with a significant reduction in plasma insulin (p = 0.019) and triglyceride (p = 0.0001) concentrations, an increase in HDL cholesterol concentration, and a decrease in low-density lipoprotein/HDL cholesterol ratio (p = 0.0001). There were no significant changes in plasma insulin, triglycerides, or HDL cholesterol concentration in the non-syndrome X group. In conclusion, weight loss attenuates coronary heart disease risk factors in obese persons with syndrome X, and the risk factor reduction is enhanced with administration of orlistat.
G Reaven; K Segal; J Hauptman; M Boldrin; C Lucas
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  87     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-29     Completed Date:  2002-01-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  827-31     Citation Subset:  AIM; IM    
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
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MeSH Terms
Anti-Obesity Agents / therapeutic use*
Cholesterol, HDL / blood
Diet, Reducing*
Double-Blind Method
Insulin / blood
Lactones / therapeutic use*
Lipase / antagonists & inhibitors*
Microvascular Angina / complications,  prevention & control*
Middle Aged
Obesity / complications,  prevention & control*
Risk Factors
Treatment Outcome
Triglycerides / blood
Weight Loss
Grant Support
Reg. No./Substance:
0/Anti-Obesity Agents; 0/Cholesterol, HDL; 0/Lactones; 0/Triglycerides; 11061-68-0/Insulin; 96829-58-2/orlistat; EC

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