Document Detail

Effect of orally and intraperitoneally administered plant lectins on food consumption of rats.
MedLine Citation:
PMID:  12903908     Owner:  NLM     Status:  MEDLINE    
A panel of orally administered lectins (100 mg/kg b.w.) of different binding specificities was tested for suppression of voluntary food consumption in prefasted rats. PHA isolectins (Phaseolus vulgaris) and RPA-I (Robinia pseudoacacia) were found to exert a marked and significant effect, but two other gut-binding lectins, i.e. SBA (Glycine max) and WGA (Triticum vulgar) and several non-binding lectins were ineffective. In cannulated rats PHA infused into the duodenum induced food suppression, i.e. binding of the lectin to the mouth or stomach was unnecessary. Suppression of food consumption lasted through the whole nocturnal feeding period, control (BSA) and experimental (PHA) curves of cumulative food consumption showed a V-like divergence. Suppression by PHA or RPA-I showed very similar time courses, but a long-lasting inhibition of gastric emptying was only observed in the RPA-treated animals. Intraperitoneally administered lectins suppressed food consumption much more effectively than the oral ones, whereas Galanthus nivalis agglutinin (ONA) had little or no effect. It is concluded that lectins can be used as effective tools for the modulation of food consumption and gastric emptying in experimental animals.
K Baintner; P Kiss; U Pfüller; Susan Bardocz; A Pusztai
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  90     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  2003  
Date Detail:
Created Date:  2003-08-07     Completed Date:  2004-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  97-107     Citation Subset:  IM    
Department of Physiology, Faculty of Animal Science, University of Kaposvár, Kaposvár, Hungary.
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MeSH Terms
Administration, Oral
Appetite Depressants / administration & dosage*,  metabolism
Feeding Behavior / drug effects*,  physiology
Gastric Emptying / drug effects,  physiology
Injections, Intraperitoneal
Plant Lectins / administration & dosage*,  metabolism
Rats, Inbred Strains
Satiety Response / drug effects*,  physiology
Reg. No./Substance:
0/Appetite Depressants; 0/Plant Lectins

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