| Effect of orally administered omeprazole on abomasal luminal pH in dairy calves fed milk replacer. | |
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MedLine Citation:
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PMID: 15943608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine whether oral administration of omeprazole, a proton-pump inhibitor, increased abomasal luminal pH in calves fed milk replacer. Four male dairy calves with cannulae in the abomasal body suckled milk replacer (60 ml/kg body weight every 12 h) and were administered a non-enteric-coated omeprazole (4 mg/kg body weight every 24 h) in a paste formulation for five successive days. Abomasal luminal pH was continuously measured using miniature glass pH electrodes. On the first day of omeprazole administration, there was a significant (P<0.05) increase in mean 24-h pH from 2.89 to 4.17. The mean 24-h pH on days 2, 3, 4 and 5 of omeprazole administration were 3.85, 4.02, 3.97 and 3.39 respectively. We conclude that oral administration of non-enteric-coated omeprazole increased abomasal luminal pH in calves fed milk replacer, but that the effect may decrease over time. |
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Authors:
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A F Ahmed; P D Constable; N A Misk |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine Volume: 52 ISSN: 0931-184X ISO Abbreviation: J Vet Med A Physiol Pathol Clin Med Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-09 Completed Date: 2005-09-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100955112 Medline TA: J Vet Med A Physiol Pathol Clin Med Country: Germany |
Other Details:
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Languages: eng Pagination: 238-43 Citation Subset: IM |
Affiliation:
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Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abomasum
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drug effects*,
physiology Administration, Oral Animal Nutritional Physiological Phenomena* Animals Animals, Newborn Animals, Suckling Anti-Ulcer Agents / administration & dosage, pharmacology* Cattle Cattle Diseases / prevention & control* Enzyme Inhibitors / administration & dosage, pharmacology* Female Hydrogen-Ion Concentration Male Omeprazole / administration & dosage, pharmacology* Stomach Ulcer / prevention & control, veterinary* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Enzyme Inhibitors; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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