Document Detail

Effect of orally administered omeprazole on abomasal luminal pH in dairy calves fed milk replacer.
MedLine Citation:
PMID:  15943608     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to determine whether oral administration of omeprazole, a proton-pump inhibitor, increased abomasal luminal pH in calves fed milk replacer. Four male dairy calves with cannulae in the abomasal body suckled milk replacer (60 ml/kg body weight every 12 h) and were administered a non-enteric-coated omeprazole (4 mg/kg body weight every 24 h) in a paste formulation for five successive days. Abomasal luminal pH was continuously measured using miniature glass pH electrodes. On the first day of omeprazole administration, there was a significant (P<0.05) increase in mean 24-h pH from 2.89 to 4.17. The mean 24-h pH on days 2, 3, 4 and 5 of omeprazole administration were 3.85, 4.02, 3.97 and 3.39 respectively. We conclude that oral administration of non-enteric-coated omeprazole increased abomasal luminal pH in calves fed milk replacer, but that the effect may decrease over time.
A F Ahmed; P D Constable; N A Misk
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine     Volume:  52     ISSN:  0931-184X     ISO Abbreviation:  J Vet Med A Physiol Pathol Clin Med     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-09     Completed Date:  2005-09-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100955112     Medline TA:  J Vet Med A Physiol Pathol Clin Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  238-43     Citation Subset:  IM    
Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
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MeSH Terms
Abomasum / drug effects*,  physiology
Administration, Oral
Animal Nutritional Physiological Phenomena*
Animals, Newborn
Animals, Suckling
Anti-Ulcer Agents / administration & dosage,  pharmacology*
Cattle Diseases / prevention & control*
Enzyme Inhibitors / administration & dosage,  pharmacology*
Hydrogen-Ion Concentration
Omeprazole / administration & dosage,  pharmacology*
Stomach Ulcer / prevention & control,  veterinary*
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Enzyme Inhibitors; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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