| Effect of orally administered epidermal growth factor on intestinal recovery of neonatal pigs infected with rotavirus. | |
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MedLine Citation:
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PMID: 7876990 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of oral epidermal growth factor (EGF) on histological and biochemical changes in epithelium in the small intestine was studied in colostrum-deprived neonatal pigs. Forty-eight pigs were infected at 4 days of age with 2 x 10(7) plaque-forming units of porcine group A rotavirus and orally fed a simulated sow-milk diet supplemented with 0.0, 0.5, or 1.0 mg/L recombinant human EGF. Sixteen noninfected pigs were fed a diet without EGF supplementation. Infected pigs developed severe diarrhea; they also consumed 25% less food and gained 60% less weight than noninfected pigs. Pigs were killed 8 days postinfection to collect samples at seven equidistant points in the small intestine. Rotavirus infection decreased villus height by 37% and reduced specific activity of lactase by 54%, of leucine aminopeptidase by 43%, and of alkaline phosphatase by 54% in the small intestine, compared with noninfected pigs. Only the supraphysiological dose of EGF (1.0 mg/L) consistently increased villus height in the proximal and mid-small intestine and lactase-specific activity in the mid-small intestine of rotavirus-infected pigs. However, this dose was only partially effective in restoring intestinal mucosal dimensions and enzyme activities. Supplemental EGF did not hasten the resolution of diarrhea. These data indicate that high physiological levels of EGF are beneficial in stimulating recovery of epithelium in the small intestine following rotavirus infection. |
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Authors:
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R T Zijlstra; J Odle; W F Hall; B W Petschow; H B Gelberg; R E Litov |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 19 ISSN: 0277-2116 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1995-04-06 Completed Date: 1995-04-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 382-90 Citation Subset: IM |
Affiliation:
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Department of Animal Sciences, University of Illinois, Urbana. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Animals, Newborn Body Weight / drug effects Diarrhea / pathology, therapy* Disease Models, Animal Epidermal Growth Factor / administration & dosage*, pharmacology Food, Fortified Intestinal Mucosa / drug effects, enzymology, pathology Intestine, Small / drug effects, enzymology*, pathology* Rotavirus Infections / pathology, therapy* Swine |
| Chemical | |
Reg. No./Substance:
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62229-50-9/Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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