Document Detail


Effect of oral supplementation of free amino acids in type 2 diabetic patients-- a pilot clinical trial.
MedLine Citation:
PMID:  11887024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Oral amino acid intake reduces plasma glucose in Streptozotocin-induced diabetic rats. This study examined the effect of oral amino acid supplementation in patients with type 2 diabetes mellitus (DM). MATERIAL/METHODS: A double blind pilot clinical trial was conducted for a period of 2 months on 77 subjects with type 2 DM. Subjects of both sexes, ages 30-60, were included in the trial. All were receiving oral antidiabetic tablets. They were divided into groups on the basis of oral supplementation: (A) lysine, (B) essential amino acids, (C) amino acids and vitamins (fat and water-soluble), and (D) calcium phosphate (control). The subjects were periodically examined for fasting and post-prandial plasma glucose, fasting and post-prandial immunoreactive insulin, plasma amino acids, glycosylated haemoglobin (HbA1c), proteins and albumin in serum, urea and creatinine in plasma and sugar, and proteins and ketones in urine. RESULTS: The results revealed a significant decrease in PP plasma glucose (P<0.05) in group B when compared to groups C and D after 45 days. Plasma Arginine was increased in group C from 3.84 to 9.24 mg/dl. There were no statistically significant changes seen in other parameters between groups and visits. CONCLUSIONS: Oral supplementation with amino acids for patients with type 2 DM appears to decrease PP plasma glucose without any change in plasma insulin levels, perhaps due to improved insulin sensitivity. However, the long term effects of amino acids need further study.
Authors:
Konerirajapuram Natarajan Sulochana; Soundarajan Lakshmi; Ranganathan Punitham; Tharigopala Arokiasamy; Baluswamy Sukumar; Sivaramakrishna Ramakrishnan
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  8     ISSN:  1234-1010     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-11     Completed Date:  2002-07-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CR131-7     Citation Subset:  IM    
Affiliation:
Biochemistry Research Department, Vision Research Foundation, Chennai, India.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Amino Acids / administration & dosage*,  metabolism,  therapeutic use*
Antioxidants / metabolism
Blood Glucose / metabolism
Body Mass Index
Diabetes Mellitus, Type 2 / drug therapy*
Double-Blind Method
Female
Humans
Insulin / blood
Lysine / metabolism
Male
Middle Aged
Pilot Projects
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Antioxidants; 0/Blood Glucose; 11061-68-0/Insulin; 56-87-1/Lysine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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