Document Detail

Effect of oral ribavirin treatment on the viral load and disease progression in Crimean-Congo hemorrhagic fever.
MedLine Citation:
PMID:  21106428     Owner:  NLM     Status:  In-Process    
OBJECTIVES: Crimean-Congo hemorrhagic fever (CCHF) is a lethal hemorrhagic disease. There is currently no specific antiviral therapy for CCHF approved for use in humans. In this study we aimed to investigate the effect of oral ribavirin treatment on the viral load and disease progression in CCHF.
METHODS: The study population was composed of patients who had a definitive diagnosis of CCHF by means of clinical presentation plus detection of viral RNA by reverse transcriptase polymerase chain reaction (RT-PCR). Ten patients who received oral ribavirin for 10 days and 40 control patients who received supportive treatment only were included in the study. Ribavirin treatment consisted of oral ribavirin 4 g/day for 4 days and then 2.4 g/day for 6 days. Viral load and hematological and biochemical laboratory parameters, which were measured daily, were analyzed.
RESULTS: Mean age (37.4 vs. 45.5, p=0.285), gender (male 50% vs. 62.5%, p=0.470), days from the appearance of symptoms to admission (4.3 vs.4.4 days, p=0.922), and initial complaints were similar between the ribavirin group and the control group. Upon hospital admission, mean viral load was 8.2×10⁸ copies/ml in the ribavirin group and 8.3×10⁸ copies/ml in the control group (p=0.994). During follow-up, no statistically significant differences were found between the groups with regard to the decrease in viral load, the reduction in alanine aminotransferase and aspartate aminotransferase levels, and the increase in platelet count. The case-fatality rate was 20% (2/10 patients) in the ribavirin group and 15% (6/40 patients) in the control group (p=0.509).
CONCLUSION: In this study, oral ribavirin treatment in CCHF patients did not affect viral load or disease progression.
Hürrem Bodur; Ayşe Erbay; Esragül Akıncı; Pınar Öngürü; Nurhayat Bayazıt; Selim Sırrı Eren; Ayhan Kubar
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Publication Detail:
Type:  Journal Article     Date:  2010-11-23
Journal Detail:
Title:  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     Volume:  15     ISSN:  1878-3511     ISO Abbreviation:  Int. J. Infect. Dis.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610933     Medline TA:  Int J Infect Dis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  e44-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Infectious Diseases and Clinical Microbiology Department, Ankara Numune Education and Research Hospital, 06100 Samanpazarı, Ankara, Turkey.
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