| EFFECT OF ORAL PHYTOESTROGEN ON ANDROGENICITY AND INSULIN SENSITIVITY IN POSTMENOPAUSAL WOMEN. | |
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MedLine Citation:
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PMID: 22077482 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: The aim of this study was to determine and compare the effect of treatment with transdermal estrogen and phytoestrogen on insulin sensitivity and SHBG levels in healthy postmenopausal women. Materials and Methods: Forty-three healthy postmenopausal women age 68 ± 7 (mean ± SD) years who were not receiving hormonal replacement therapy completed a three month randomized drug therapy study. The participants were randomized to one of four groups: 0.05 mg or 0.1 mg transdermal estrogen/day, or 40 or 80 mg oral phytoestrogen (Promensil)/day Insulin sensitivity was indirectly measured using the Quantitative insulin sensitivity check index (QUICKI). Sex hormone-binding globulin (SHBG), total testosterone, estradiol, and fasting glucose and insulin levels for calculation of insulin sensitivity were obtained at baseline and at monthly intervals during 3 months of therapy. Results: In healthy nondiabetic postmenopausal women, the rate of change in QUICKI was significantly different between the red clover based phytoestrogen and transdermal estrogen groups, so that after three months of therapy, QUICKI with red clover based phytoestrogen therapy was lower than that in the transdermal estrogen group, p = 0.01. Red clover based phytoestrogen therapy was not associated with any changes in SHBG levels whereas transdermal estrogen therapy significantly increased SHBG levels, p = 0.05. Conclusions: In contrast to transdermal estrogen therapy, oral phytoestrogen therapy does not decrease androgenicity and is associated with a decrease in insulin sensitivity. These effects are similar to those of raloxifene and consistent with phytoestrogen's selective estrogen receptor modulator (SERM) properties. |
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Authors:
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Cathy C Lee; Cathie J Bloem; Josephine Z Kasa-Vubu; Li-Jung Liang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-12 |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: - ISSN: 1463-1326 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA VA Greater Los Angeles Healthcare System Geriatric Research Education and Clinical Center, Los Angeles, CA University of Michigan, Ann Arbor, MI Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan Health System, Ann Arbor, MI. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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