| Effect of oral nalmefene, an opiate-receptor antagonist, on meal-stimulated gastric acid secretion and serum gastrin concentration in man. | |
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MedLine Citation:
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PMID: 4059587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated whether nalmefene, an orally administered opiate-receptor antagonist, would inhibit gastric acid secretion in response to a meal in healthy humans. On separate days either 50 mg nalmefene or a placebo tablet was administered by mouth 90 min before a blenderized steak meal was infused into the stomach through a nasogastric tube. Compared to placebo, nalmefene inhibited meal-stimulated acid secretion in each of 6 subjects studied (P less than 0.05). During the second and third hours after the meal, nalmefene inhibited mean acid secretion by 16%. Nalmefene also resulted in significantly higher meal-stimulated serum gastrin concentrations than placebo (P less than 0.05) even though intragastric pH was kept constant at 5.0 in both experiments. These studies indicate that an orally administered opiate-receptor antagonist can inhibit gastric acid secretion in response to a meal in humans, yet increase meal-stimulated serum gastrin concentrations. |
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Authors:
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M Feldman; L Moore; J H Walsh |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Regulatory peptides Volume: 11 ISSN: 0167-0115 ISO Abbreviation: Regul. Pept. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-12-11 Completed Date: 1985-12-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 245-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Appetite Depressants / pharmacology* Eating Female Gastric Acid / secretion* Gastric Juice / drug effects Gastrins / blood* Humans Kinetics Male Naltrexone / analogs & derivatives*, pharmacology Placebos Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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AM 16816/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Appetite Depressants; 0/Gastrins; 0/Placebos; 16590-41-3/Naltrexone; 55096-26-9/nalmefene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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