Document Detail

Effect of oral nalmefene, an opiate-receptor antagonist, on meal-stimulated gastric acid secretion and serum gastrin concentration in man.
MedLine Citation:
PMID:  4059587     Owner:  NLM     Status:  MEDLINE    
We evaluated whether nalmefene, an orally administered opiate-receptor antagonist, would inhibit gastric acid secretion in response to a meal in healthy humans. On separate days either 50 mg nalmefene or a placebo tablet was administered by mouth 90 min before a blenderized steak meal was infused into the stomach through a nasogastric tube. Compared to placebo, nalmefene inhibited meal-stimulated acid secretion in each of 6 subjects studied (P less than 0.05). During the second and third hours after the meal, nalmefene inhibited mean acid secretion by 16%. Nalmefene also resulted in significantly higher meal-stimulated serum gastrin concentrations than placebo (P less than 0.05) even though intragastric pH was kept constant at 5.0 in both experiments. These studies indicate that an orally administered opiate-receptor antagonist can inhibit gastric acid secretion in response to a meal in humans, yet increase meal-stimulated serum gastrin concentrations.
M Feldman; L Moore; J H Walsh
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Regulatory peptides     Volume:  11     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-12-11     Completed Date:  1985-12-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  245-50     Citation Subset:  IM    
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MeSH Terms
Appetite Depressants / pharmacology*
Gastric Acid / secretion*
Gastric Juice / drug effects
Gastrins / blood*
Naltrexone / analogs & derivatives*,  pharmacology
Time Factors
Grant Support
Reg. No./Substance:
0/Appetite Depressants; 0/Gastrins; 0/Placebos; 16590-41-3/Naltrexone; 55096-26-9/nalmefene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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