Document Detail

Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction.
MedLine Citation:
PMID:  17413949     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the effect of oral linoleic and gamma-linolenic acid, 2 omega-6 essential fatty acids, on meibomian gland dysfunction (MGD). METHODS: Fifty-seven patients with MGD (27 men and 30 women) were randomly divided into 3 groups of 19. Group A received tablets containing linoleic acid (28.5 mg) and gamma-linolenic acid (15 mg) once daily. Group B performed eyelid hygiene once daily. Group C received both treatments. Initially and after 60 and 180 days of therapy, all patients completed a self-evaluation questionnaire on ocular surface disorders and underwent slit-lamp examination. The following signs were evaluated: eyelid edema, eyelid margin hyperemia, meibomian secretion appearance, meibomian gland obstruction, foam collection in the tear meniscus, conjunctival hyperemia, conjunctival papillae, and corneal staining. RESULTS: Statistically significant improvement in symptoms occurred in all groups. After 180-day therapy, group A showed significant reduction in secretion turbidity (P = 0.02) and meibomian gland obstruction (P = 0.0001), whereas group B had significant reduction in eyelid edema (P = 0.02), corneal staining (P = 0.01), secretion turbidity (P = 0.01), and meibomian gland obstruction (P = 0.0001). Group C had significant reduction in eyelid edema (P = 0.003), foam collection in the tear meniscus (P = 0.02), corneal staining (P = 0.02), secretion turbidity (P = 0.0001), and meibomian gland obstruction (P = 0.0001). CONCLUSIONS: Therapy with linoleic and gamma-linolenic acid tablets along with eyelid hygiene improves symptoms and reduces eyelid margin inflammation in MGD more than either omega-6 fatty acids or eyelid hygiene alone.
Antonio Pinna; Paola Piccinini; Francesco Carta
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Cornea     Volume:  26     ISSN:  0277-3740     ISO Abbreviation:  Cornea     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  260-4     Citation Subset:  IM    
Institute of Ophthalmology, University of Sassari, Sassari, Italy.
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MeSH Terms
Administration, Oral
Aged, 80 and over
Eyelid Diseases / drug therapy*,  physiopathology
Linoleic Acid / therapeutic use*
Meibomian Glands / drug effects*,  physiopathology
Middle Aged
Treatment Outcome
gamma-Linolenic Acid / therapeutic use*
Reg. No./Substance:
2197-37-7/Linoleic Acid; 506-26-3/gamma-Linolenic Acid

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