| Effect of oral ketorolac and gender on human cold pressor pain tolerance. | |
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MedLine Citation:
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PMID: 14516415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Although the analgesic effect of opioids on experimental cold pressor (CP) pain has been well demonstrated, the analgesic effect of non-steroidal anti-inflammatory drugs (NSAIDs) on experimental CP pain has been less reliable, a finding complicated by inconsistencies in how CP analgesic effect is measured. 2. In the present study, a clinically relevant CP response of pain tolerance was used to assess the previously undescribed analgesic efficacy of the potent NSAID ketorolac (10 mg, p.o.), on CP pain across gender in a sample of normal subjects (n = 50). 3. Using a placebo-controlled crossover design, neither a main nor interaction effect for ketorolac on CP pain tolerance was detected. When examined by gender, male subjects exhibited a large placebo response to CP pain under study conditions, whereas women (albeit less pain tolerant at baseline) evidenced no placebo effect but a modest-to-good NSAID analgesic response. 4. Findings on the gender-specific placebo and analgesic NSAID response, integrated with the current literature, indicate that the lack of NSAID analgesic efficacy in the CP pain model may be related to unexamined and differential effects of how gender affects NSAID analgesic effect. |
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Authors:
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Peggy Compton; V C Charuvastra; Walter Ling |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 30 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-30 Completed Date: 2004-06-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
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Languages: eng Pagination: 759-63 Citation Subset: IM |
Affiliation:
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School of Nursing, University of California at Los Angeles, Los Angeles, California, USA. pcompton@sonnet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Analysis of Variance Cold Temperature / adverse effects* Cross-Over Studies Double-Blind Method Female Humans Ketorolac / administration & dosage* Male Middle Aged Pain / drug therapy*, physiopathology Pain Threshold / drug effects*, physiology Sex Characteristics* |
| Grant Support | |
ID/Acronym/Agency:
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1R03DA09866/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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66635-83-4/Ketorolac |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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