Document Detail

Effect of oral contraceptives on endothelial function in the peripheral microcirculation of healthy women.
MedLine Citation:
PMID:  14654747     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We assessed whether third-generation oral contraceptive (OC) treatment (30 microg ethinylestradiol + 75 microg gestodene daily) could affect the endothelial function of healthy women. METHODS: In 20 young healthy women (HW) and 10 hypercholesterolemic women (CW) we assessed forearm blood flow (strain-gauge plethysmography) changes induced by the intrabrachial infusion of acetylcholine (ACH) (0.15-15 microg/100 ml forearm tissue/min) and sodium nitroprusside (SNP) (1-4 microg/100 ml forearm tissue/min). ACH was repeated during the nitric oxide synthase inhibitor intra-arterial NG-monomethyl-L-arginine (L-NMMA) (100 microg/100 ml forearm tissue/min) or the antioxidant vitamin C (8 mg/100 ml forearm tissue/min). HW repeated the protocol after 6-month OC (n = 10) or placebo (n = 10) treatment. RESULTS: In HW the maximal vasodilation to ACH, similar between placebo and OC subgroups, was significantly reduced in CW (P < 0.01). Vasodilation to ACH was blunted (P < 0.01) by L-NMMA and unaffected by vitamin C, in both OC and placebo groups. In CW the vasodilation to ACH, not modified by L-NMMA, was improved by vitamin C (P < 0.01). OC treatment raised (P < 0.01) plasma total and low-density lipoprotein cholesterol, and values were similar to those shown by CW. Both OC and placebo intake did not change the response to ACH and the modulation induced by L-NMMA or vitamin C. Vasodilation to SNP was similar in all groups. CONCLUSIONS: In HW 6-month treatment with third-generation OC, although associated with an abnormal lipid profile, does not adversely affect endothelium-dependent vasodilation. This neutral effect could be the balance between a deleterious effect of hypercholesterolemia and a protective effect of OC on endothelial function.
Agostino Virdis; Stefania Pinto; Daniele Versari; Guido Salvetti; Gianpaolo Bernini; Franca Fruzzetti; Andrea R Genazzani; Stefano Taddei; Antonio Salvetti
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  21     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-05     Completed Date:  2004-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2275-80     Citation Subset:  IM    
Department of Internal Medicine, University of Pisa, Italy.
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MeSH Terms
Acetylcholine / administration & dosage
Antioxidants / administration & dosage
Ascorbic Acid / administration & dosage
Biological Markers / blood
Cholesterol, LDL / blood,  drug effects
Contraceptives, Oral / administration & dosage*
Dose-Response Relationship, Drug
Endothelium, Vascular / drug effects*,  metabolism,  physiology*
Enzyme Inhibitors / administration & dosage
Forearm / blood supply*
Hypercholesterolemia / blood,  physiopathology
Microcirculation / drug effects
Nitroprusside / administration & dosage
Reference Values
Regional Blood Flow / drug effects
Triglycerides / blood
Vasodilation / drug effects
Vasodilator Agents / administration & dosage
Women's Health
omega-N-Methylarginine / administration & dosage
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Cholesterol, LDL; 0/Contraceptives, Oral; 0/Enzyme Inhibitors; 0/Triglycerides; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 17035-90-4/omega-N-Methylarginine; 50-81-7/Ascorbic Acid; 51-84-3/Acetylcholine
Comment In:
J Hypertens. 2003 Dec;21(12):2227-30   [PMID:  14654737 ]

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