Document Detail

Effect of an oral beta2-adrenergic agonist on lower esophageal sphincter pressure in normals and in patients with achalasia.
MedLine Citation:
PMID:  6129117     Owner:  NLM     Status:  MEDLINE    
The effect of the beta2-adrenergic agonist, carbuterol, was studied on the lower esophageal sphincter (LES) pressure in normals and in patients with achalasia. In normals, the mean LES pressure decreased from 23.1 +/- 6.2 mm Hg (mean +/- SEM) to 16.0 +/- 5.0 mm Hg at a 4.0-mg dose of carbuterol (P less than 0.05). In patients with achalasia, the mean LES pressure decreased from 50.1 +/- 5.1 mm Hg to 22.7 +/- 2.4 mm Hg after a 4.0-mg dose of carbuterol (P less than 0.01). The duration of action following oral administration exceeded 90 min. These studies indicate that the LES in man has beta2-adrenergic receptors that mediate a reduction in pressure. The magnitude of LES pressure reduction in patients with achalasia suggests that this drug may be of therapeutic benefit.
A J DiMarino; S Cohen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  27     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1063-6     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Adrenergic beta-Agonists / administration & dosage,  pharmacology*,  therapeutic use
Dose-Response Relationship, Drug
Esophageal Achalasia / drug therapy*
Esophagogastric Junction / drug effects*
Ethanolamines / administration & dosage,  pharmacology,  therapeutic use
Middle Aged
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Ethanolamines; 34866-47-2/carbuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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