Document Detail


Effect of oral administration of delta-tetrahydrocannabinol on airway mechanics in normal and asthmatic subjects.
MedLine Citation:
PMID:  789025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We performed a double-blind study on the effect of oral administration of 10 mg of delta9-tetrahydrocannabinol on specific airway conductance (Gaw/VL) and the maximal expiratory flow at 50% of vital capacity (Vmax 50%) in six control and six asthmatic subjects. In control subjects, there was a slight but statistically significant increase in Gaw/VL after oral administration of delta9-tetrahydrocannabinol; however, there was no significant increase in Vmax 50%. One of the asthmatic patients developed severe bronchoconstriction following administration of delta9-tetrahydrocannabinol; among the remaining five patients, there were variable changes in Gaw/VL and Vmax 50% after oral administration of delta9-tetrahydrocannabinol, but mean changes were not significant. Mild effects on the central nervous system (CNS) were observed in three subjects; six subjects, three of whom had unpleasant mood changes, had more prominent CNS effects. We concluded that oral administration of delta9-tetrahydrocannabinol is unlikely to be of therepeutic value in asthma, since its bronchodilator action was mild and inconstant and was associated with significant CNS effects. Moreover, one asthmatic patient developed severe bronchoconstriction following oral administration of delta 9-tetrahydrocannabinol.
Authors:
R T Abboud; H D Sanders
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Chest     Volume:  70     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  480-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Airway Resistance / drug effects
Asthma / drug therapy*
Clinical Trials as Topic
Drug Evaluation
Female
Forced Expiratory Volume
Functional Residual Capacity
Heart Rate / drug effects
Humans
Male
Middle Aged
Pulmonary Ventilation / drug effects*
Tetrahydrocannabinol / adverse effects,  pharmacology,  therapeutic use*
Total Lung Capacity
Vital Capacity / drug effects
Chemical
Reg. No./Substance:
1972-08-3/Tetrahydrocannabinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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