Document Detail

Effect of opioid antagonism on esophageal temperature during exercise.
MedLine Citation:
PMID:  3173046     Owner:  NLM     Status:  MEDLINE    
The effect of naloxone-induced endogenous opioid antagonism on core temperature control during exercise was studied in 8 competitive cyclists. Volume-matched infusions of placebo or 2 mg of naloxone were administered, in a randomized double-blind crossover fashion, prior to maximal graded cycle ergometer exercise testing. Esophageal (Tes), rectal (Tre) and oral (Tor) temperatures were measured before and after exercise, and Tes was continuously measured during exercise. Cardiorespiratory responses and maximal exercise duration were unaffected by naloxone. Naloxone did not significantly modify the Tes response or the highest Tre and Tor elicited by exercise testing. The rise in Tes (placebo: 2.2 +/- 0.4 degrees C; naloxone: 2.1 +/- 0.4 degrees C) and Tre (placebo: 1.1 +/- 0.2 degree C; naloxone: 0.9 +/- 0.4 degree C) was significant (p less than 0.001) with and without naloxone, whereas the rise in Tor was significant (p less than 0.05) with placebo (0.5 +/- 0.5 degree C) but not with naloxone (0 +/- 0.8 degree C, p greater than 0.5). These data indicate that although 2 mg of naloxone might alter heat exchange in the oral cavity during exercise, it does not modify the actual core temperature response. Therefore, insofar as this dosage of naloxone may be used to examine the functional role of opioid-mediated mechanisms, our findings are not tenable with the hypothesis that endogenous opioids play a role in maintenance of thermal homeostasis during exercise.
M P Schwellnus; N F Gordon
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  20     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-16     Completed Date:  1988-11-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  381-4     Citation Subset:  IM; S    
I Military Hospital Cardiac Rehabilitation Centre, Pretoria, South Africa.
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MeSH Terms
Body Temperature Regulation / drug effects*
Double-Blind Method
Endorphins / antagonists & inhibitors*
Esophagus / drug effects,  physiology*
Heart Rate / drug effects
Infusions, Intravenous
Naloxone / administration & dosage,  pharmacology*
Random Allocation
Reg. No./Substance:
0/Endorphins; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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