Document Detail


Effect of opioid antagonism on conditioned place preferences to snack foods.
MedLine Citation:
PMID:  16540156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous research has shown that food-deprived rats acquire conditioned place preferences (CPPs) to sweet liquids that are largely attenuated by the opioid antagonist naltrexone (NAL). This study determined if ad libitum Chow-fed rats can learn CPPs when given relatively brief exposures to different solid snack foods (SFs) -- one high in sugar (Froot Loops cereal: FL) vs. one high in fat (Cheetos: C). Two groups of 16 male rats were trained during 20-min sessions to eat either FL or C in one side of a three-chambered CPP apparatus vs. Chow in the opposite side on alternating days for 20 days. Rats ate considerably more SFs of both types than Chow during the conditioning sessions (SFs: about 23 kcal versus Chow: about 7 kcal). Ten-minute tests for CPPs in the absence of SFs showed that the time spent on SF-conditioned sides increased significantly compared to pre-conditioning tests. Analyses of variance for re-tested CCPs after 0.1, 1.0, 2.5, and 5.0mg/kg NAL showed dose-dependent suppressions of CPPs to both SFs. These data show that consuming sweet or fatty SFs can become reliably associated with environmental cues in the non-deprived state. The endogenous opioid system, which mediates hedonic aspects of palatable food intake, appears to mediate these learned associations.
Authors:
Patricia A Jarosz; Phawanjit Sekhon; Donald V Coscina
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Publication Detail:
Type:  Journal Article     Date:  2006-03-15
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  83     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-04-21     Completed Date:  2006-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  257-64     Citation Subset:  IM    
Affiliation:
College of Nursing, Wayne State University, 5557 Cass Avenue, Detroit, MI 48202, USA. pjarosz@wayne.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Conditioning, Operant*
Male
Naltrexone / administration & dosage
Narcotic Antagonists / pharmacology*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Narcotic Antagonists; 16590-41-3/Naltrexone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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