Document Detail

Effect of ongoing inflammation in rheumatoid arthritis on P-wave dispersion.
MedLine Citation:
PMID:  18034993     Owner:  NLM     Status:  MEDLINE    
It has been emphasized recently that there is a strong association between atrial fibrillation and inflammation. Rheumatoid arthritis (RA), characterized by ongoing inflammatory activity, can increase the risk of atrial arrhythmia. P-wave dispersion has been encountered as a risk factor for atrial fibrillation and the effect of inflammation on P-wave dispersion has not been studied thoroughly. The aim of this study was to examine the effect of ongoing inflammatory activity in RA on P-wave dispersion. The study comprised 82 patients diagnosed with RA and 41 healthy volunteers as controls. Systolic functions of all participants were evaluated by echocardiography. Maximum P-wave duration and dispersion were calculated and found to be significantly increased in the RA group compared with the healthy controls. These parameters were also significantly correlated with C-reactive protein levels. The findings of this study suggest that RA may be associated with increases in P-wave dispersion and maximum P-wave duration, and that this association may result from ongoing inflammation.
M Yavuzkir; A Ozturk; N Dagli; S Koca; I Karaca; M Balin; A Işik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  35     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-11-23     Completed Date:  2008-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  796-802     Citation Subset:  IM    
Department of Cardiology, Firat University, School of Medicine, Elazig, Turkey.
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MeSH Terms
Arthritis, Rheumatoid* / complications,  pathology
Atrial Fibrillation / etiology*
C-Reactive Protein / metabolism
Inflammation / complications*
Middle Aged
Risk Factors
Reg. No./Substance:
9007-41-4/C-Reactive Protein

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