| Effect of one-month treatment with nonsteroidal antiinflammatory drugs (NSAIDs) on gastric pH of rheumatoid arthritis patients. | |
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MedLine Citation:
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PMID: 9539637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of NSAIDs is strongly associated with peptic ulceration. The inhibition of prostaglandin synthesis with the consequent increase of gastric acidity is considered a possible mechanism. Therefore we decided to assess the effect of one-month treatment with NSAIDs on the circadian gastric pH of rheumatoid arthritis (RA) patients. We studied 11 consecutive patients (one man and 10 women, median age 55, range 26-72 years) with confirmed RA. None was H. pylori positive. A 24-hr gastric pH recording was performed both in basal conditions and after one-month treatment with either indomethacin 150 mg/day (eight cases) or ketoprofen 300 mg/day (three cases). Only the 10 female patients were eligible for final analysis, and six matched healthy subjects not taking NSAIDs were used as control group. The number of 24-hr pH readings for various pH thresholds was calculated for both populations. The highest acid levels (pH < 3.0) did not differ between the two pH profiles of the control group (7440 vs 7391, P = NS), while they predominated after the one-month NSAID treatment (10,339 vs 11,440, P < 0.001) in RA patients. These findings show that there is an increased gastric acidity after one-month of treatment with NSAIDs in female patients with RA of recent onset. This may sustain the rationale of using antisecretory agents to prevent gastroduodenal ulcerations in these patients. |
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Authors:
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V Savarino; G S Mela; P Zentilin; M A Cimmino; M Parisi; M R Mele; M Pivari; G Bisso; G Celle |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 43 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-04-21 Completed Date: 1998-04-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 459-63 Citation Subset: AIM; IM |
Affiliation:
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Dipartimento di Medicina Interna, Cattedra di Gastroenterologia and Reumatologia, Università di Genova, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Anti-Inflammatory Agents, Non-Steroidal / therapeutic use* Arthritis, Rheumatoid / drug therapy*, metabolism Case-Control Studies Circadian Rhythm Female Gastric Acid / secretion* Gastric Acidity Determination Humans Hydrogen-Ion Concentration Indomethacin / therapeutic use* Ketoprofen / therapeutic use* Male Middle Aged Monitoring, Ambulatory Peptic Ulcer / prevention & control Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 22071-15-4/Ketoprofen; 53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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