Document Detail

Effect of one-month treatment with nonsteroidal antiinflammatory drugs (NSAIDs) on gastric pH of rheumatoid arthritis patients.
MedLine Citation:
PMID:  9539637     Owner:  NLM     Status:  MEDLINE    
The use of NSAIDs is strongly associated with peptic ulceration. The inhibition of prostaglandin synthesis with the consequent increase of gastric acidity is considered a possible mechanism. Therefore we decided to assess the effect of one-month treatment with NSAIDs on the circadian gastric pH of rheumatoid arthritis (RA) patients. We studied 11 consecutive patients (one man and 10 women, median age 55, range 26-72 years) with confirmed RA. None was H. pylori positive. A 24-hr gastric pH recording was performed both in basal conditions and after one-month treatment with either indomethacin 150 mg/day (eight cases) or ketoprofen 300 mg/day (three cases). Only the 10 female patients were eligible for final analysis, and six matched healthy subjects not taking NSAIDs were used as control group. The number of 24-hr pH readings for various pH thresholds was calculated for both populations. The highest acid levels (pH < 3.0) did not differ between the two pH profiles of the control group (7440 vs 7391, P = NS), while they predominated after the one-month NSAID treatment (10,339 vs 11,440, P < 0.001) in RA patients. These findings show that there is an increased gastric acidity after one-month of treatment with NSAIDs in female patients with RA of recent onset. This may sustain the rationale of using antisecretory agents to prevent gastroduodenal ulcerations in these patients.
V Savarino; G S Mela; P Zentilin; M A Cimmino; M Parisi; M R Mele; M Pivari; G Bisso; G Celle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  43     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-04-21     Completed Date:  1998-04-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  459-63     Citation Subset:  AIM; IM    
Dipartimento di Medicina Interna, Cattedra di Gastroenterologia and Reumatologia, Università di Genova, Italy.
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MeSH Terms
Administration, Oral
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Arthritis, Rheumatoid / drug therapy*,  metabolism
Case-Control Studies
Circadian Rhythm
Gastric Acid / secretion*
Gastric Acidity Determination
Hydrogen-Ion Concentration
Indomethacin / therapeutic use*
Ketoprofen / therapeutic use*
Middle Aged
Monitoring, Ambulatory
Peptic Ulcer / prevention & control
Time Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 22071-15-4/Ketoprofen; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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