Document Detail

Effect of oncotic pressure of diaspirin cross-linked hemoglobin (DCLHb) on brain injury after temporary focal cerebral ischemia in rats.
MedLine Citation:
PMID:  8694316     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that diaspirin cross-linked hemoglobin (DCLHb, 10 g/dL) decreases cerebral ischemia and the resultant injury in a dose-dependent manner, requiring large volumes of DCLHb for maximum efficacy. We assessed the effect of a more concentrated (20 g/dL) and more hyperoncotic preparation of DCLHb on cerebral infarction volume. Immediately after middle cerebral artery occlusion, rats were randomized to one of the following groups: Control, hematocrit not manipulated; 10/Hb, hematocrit decreased to 30% with 10% DCLHb (oncotic pressure 43 mm Hg); 7.5/Alb, hematocrit decreased to 30% with 7.5% albumin (oncotic pressure 43 mm Hg); 20/Hb, the same dose of DCLHb (20%, oncotic pressure 129 mm Hg) as the 10/HB group (half the volume); or 15/Alb, the same dose of albumin (15%, oncotic pressure 130 mm Hg) as the 7.5/Alb group half the volume). After 90 min of ischemia, 72 h of reperfusion was allowed. Infarction volume (mm3, mean +/- sd) was less in the DCLHb groups (10/Hb = 79 +/- 17; 20/HB = 51 +/- 14) than the oncotically matched albumin groups (7.5/Alb = 124 +/- 21; 15/Alb = 85 +/- 18) and the Control group (135 +/- 17) (P < 0.05). These data indicate that in this model of cerebral ischemia, DCLHb decreases ischemic brain injury more effectively than albumin, and that a hyperoncotic preparation of DCLHb is preferable.
D J Cole; J C Drummond; P M Patel; J C Nary; R L Applegate
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  83     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-08-29     Completed Date:  1996-08-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  342-7     Citation Subset:  AIM; IM    
Department of Anesthesiology, Loma Linda University, California 92354, USA.
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MeSH Terms
Aspirin / administration & dosage,  analogs & derivatives*,  therapeutic use
Blood Volume
Brain / drug effects*,  pathology
Cerebral Infarction / pathology,  prevention & control*
Coloring Agents / diagnostic use
Dose-Response Relationship, Drug
Exchange Transfusion, Whole Blood
Hemoglobins / administration & dosage,  therapeutic use*
Ischemic Attack, Transient / drug therapy*
Osmotic Pressure
Random Allocation
Rats, Inbred SHR
Serum Albumin / administration & dosage,  therapeutic use
Tetrazolium Salts / diagnostic use
Reg. No./Substance:
0/Coloring Agents; 0/Hemoglobins; 0/Serum Albumin; 0/Tetrazolium Salts; 0/diaspirin-cross-linked hemoglobin; 50-78-2/Aspirin; 902-00-1/triphenyltetrazolium

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