| Effect of omeprazole treatment on feed intake and blood gastrin and pepsinogen levels in the calf. | |
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MedLine Citation:
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PMID: 2704894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous work has shown blood gastrin levels to be elevated and appetite depressed in ostertagia-infected calves. A possible relationship between raised blood gastrin values and feed intake was investigated in worm-free animals using the human gastric acid secretion inhibitor, omeprazole. An initial dose-titration experiment established that administration of the drug by intravenous injection at 1.95 mg kg-1 (four times the recommended human dose rate) resulted in a marked (5.2-fold) increase in blood gastrin levels in the calf. Daily administration of omeprazole by intravenous injection at 2 mg kg-1 for four days in a subsequent experiment resulted in a significant depression in feed intake (up to 40.4 per cent) which was accompanied by a significant rise in blood gastrin levels (peak 940 pg ml-1; 6.5-fold increase over control values). It is suggested that such a rise in hormone levels would reduce reticuloruminal and abomasal motility, slow down the passage of ingesta and, in turn, lead to a reduction in appetite. |
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Authors:
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M T Fox; D Gerrelli; P Shivalkar; D E Jacobs |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Research in veterinary science Volume: 46 ISSN: 0034-5288 ISO Abbreviation: Res. Vet. Sci. Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-05-19 Completed Date: 1989-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 280-2 Citation Subset: IM |
Affiliation:
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Department of Veterinary Pathology, Royal Veterinary College, London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Appetite Regulation / drug effects* Cattle / blood, physiology* Drug Administration Schedule Female Gastrins / blood Injections, Intravenous Omeprazole / administration & dosage, pharmacology* Pepsinogens / blood |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 0/Pepsinogens; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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