Document Detail

Effect of omeprazole treatment on feed intake and blood gastrin and pepsinogen levels in the calf.
MedLine Citation:
PMID:  2704894     Owner:  NLM     Status:  MEDLINE    
Previous work has shown blood gastrin levels to be elevated and appetite depressed in ostertagia-infected calves. A possible relationship between raised blood gastrin values and feed intake was investigated in worm-free animals using the human gastric acid secretion inhibitor, omeprazole. An initial dose-titration experiment established that administration of the drug by intravenous injection at 1.95 mg kg-1 (four times the recommended human dose rate) resulted in a marked (5.2-fold) increase in blood gastrin levels in the calf. Daily administration of omeprazole by intravenous injection at 2 mg kg-1 for four days in a subsequent experiment resulted in a significant depression in feed intake (up to 40.4 per cent) which was accompanied by a significant rise in blood gastrin levels (peak 940 pg ml-1; 6.5-fold increase over control values). It is suggested that such a rise in hormone levels would reduce reticuloruminal and abomasal motility, slow down the passage of ingesta and, in turn, lead to a reduction in appetite.
M T Fox; D Gerrelli; P Shivalkar; D E Jacobs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research in veterinary science     Volume:  46     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-05-19     Completed Date:  1989-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  280-2     Citation Subset:  IM    
Department of Veterinary Pathology, Royal Veterinary College, London.
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MeSH Terms
Administration, Oral
Appetite Regulation / drug effects*
Cattle / blood,  physiology*
Drug Administration Schedule
Gastrins / blood
Injections, Intravenous
Omeprazole / administration & dosage,  pharmacology*
Pepsinogens / blood
Reg. No./Substance:
0/Gastrins; 0/Pepsinogens; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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