Document Detail


Effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux.
MedLine Citation:
PMID:  15793885     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To value whether omeprazole could induce the healing of DIS and regression of symptoms in patients with DGER. METHODS: We enrolled 15 symptomatic patients with a pathological esophageal 24-h pH-metry and bilimetry. Patients underwent endoscopy and biopsies were taken from the distal esophagus. Specimens were analyzed at histology and transmission electron microscopy (TEM). Patients were treated with omeprazole 40 mg/d for 3 mo and then endoscopy with biopsies was repeated. Patients with persistent heartburn and/or with an incomplete recovery of DIS were treated for 3 more months and endoscopy with biopsies was performed. RESULTS: Nine patients had a non-erosive reflux disease at endoscopy (NERD) while 6 had erosive esophagitis (ERD). At histology, of the 6 patients with erosive esophagitis, 5 had mild esophagitis and 1 moderate esophagitis. No patients with NERD showed histological signs of esophagitis. After 3 mo of therapy, 13/15 patients (86.7%, P<0.01) showed a complete recovery of DIS and disappearance of heartburn. Of the 2 patients treated for 3 more months, complete recovery of DIS and heartburn were achieved in one. CONCLUSION: Three or 6 mo of omeprazole therapy led to a complete regression of the ultrastructural esophageal damage in 86.7% and in 93% of patients with DGER, NERD and ERD respectively. The ultrastructural recovery of the epithelium was accompanied by regression of heartburn in all cases.
Authors:
Carlo Calabrese; Anna Fabbri; Mauro Bortolotti; Giovanna Cenacchi; Scialpi Carlo; Desiree Zahlane; Mario Miglioli; Giulio Di Febo
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  11     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-28     Completed Date:  2005-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1876-80     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Gastroenterology, Policlinico S. Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy. calabrese.c@med.unibo.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Ulcer Agents / administration & dosage*
Epithelial Cells / drug effects,  pathology,  ultrastructure
Esophagitis, Peptic / drug therapy*,  pathology*
Esophagus / drug effects*,  pathology,  ultrastructure
Female
Humans
Male
Microscopy, Electron, Transmission
Middle Aged
Mucous Membrane / drug effects,  pathology,  ultrastructure
Omeprazole / administration & dosage*
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 73590-58-6/Omeprazole

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