Document Detail


Effect of omeprazole on gastric first-pass metabolism of ethanol.
MedLine Citation:
PMID:  1587193     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some commonly used H2-receptor antagonists affect gastric first-pass metabolism of ethanol and lead to unexpectedly high blood alcohol concentrations after consumption of alcohol. To investigate whether omeprazole--a substituted benzimidazole recently approved for clinical use--has a similar harmful effect, we administered a moderate dose of ethanol (0.3 g/kg body wt) orally to seven normal volunteers before and after one week of omeprazole administration (20 mg daily). No significant effect of the drug was found on either mean peak blood alcohol concentrations or on areas under the blood alcohol curve; neither did these parameters differ significantly before or after an acute dose of omeprazole (13.2 mg/kg body wt) in rats, whether ethanol (0.25 g/kg body wt) was administered intragastrically or intravenously. In vitro, omeprazole in concentrations likely to occur in the gastric lumen (0.01-1.0 mM), did not affect gastric alcohol dehydrogenase activity of humans or rats. Thus omeprazole does not affect gastric first-pass metabolism of ethanol and can be considered as a safe choice for the treatment of patients who do not refrain from alcohol consumption during therapy.
Authors:
R Roine; R Hernández-Muñoz; E Baraona; R Greenstein; C S Lieber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  37     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-06-22     Completed Date:  1992-06-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  891-6     Citation Subset:  AIM; IM    
Affiliation:
Section of Liver Diseases, Bronx Veterans Administration Medical Center, New York 10468.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Dehydrogenase / metabolism*
Animals
Ethanol / blood,  metabolism*
Humans
Liver / enzymology
Male
Omeprazole / pharmacology*
Rats
Rats, Inbred Strains
Stomach / enzymology,  metabolism*
Grant Support
ID/Acronym/Agency:
AA03508/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol; 73590-58-6/Omeprazole; EC 1.1.1.1/Alcohol Dehydrogenase
Comments/Corrections
Comment In:
Dig Dis Sci. 1993 Mar;38(3):569-73   [PMID:  8095199 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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