Document Detail

Effect of omega 3 and omega 6 fatty acid intakes from diet and supplements on plasma fatty acid levels in the first 3 years of life.
MedLine Citation:
PMID:  19114389     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The optimal method for conducting omega (n-)3 polyunsaturated fatty acid (PUFA) supplementation trials in children is unknown. AIM: To assess the impact of n-3 and n-6 PUFA intake from the background diet on plasma levels of n-3 and n-6 PUFA in children aged 0-3 years, with and without n-3 supplementation. METHODS: Subjects were randomised antenatally to receive either n-3 PUFA supplements and low n-6 PUFA cooking oils and spreads or a control intervention, designed to maintain usual fatty acid intake. Dietary intake was assessed at 18 months by 3-day weighed food record and at 3 years by food frequency questionnaire. Plasma phospholipids were measured at both time points. Associations were tested by regression. RESULTS: N-3 PUFA intake from background diet did not significantly affect plasma n-3 levels. In contrast, n-6 PUFA intake in background diet was positively related to plasma n-6 levels in both study groups. In addition, n-6 PUFA intake from diet was negatively associated with plasma n-3 levels at 18 months and 3 years (-0.16%/g n-6 intake, 95%CI -0.29 to -0.03 and -0.05%/g n-6 intake, 95%CI -0.09 to -0.01, respectively) in the active group, but not in the control group. CONCLUSION: Interventions intending to increase plasma n-3 PUFA in children by n-3 supplementation should also minimise n-6 PUFA intake in the background diet.
Camilla Hoyos; Catarina Almqvist; Frances Garden; Wei Xuan; Wendy H Oddy; Guy B Marks; Karen L Webb
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Asia Pacific journal of clinical nutrition     Volume:  17     ISSN:  0964-7058     ISO Abbreviation:  Asia Pac J Clin Nutr     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-30     Completed Date:  2009-04-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9440304     Medline TA:  Asia Pac J Clin Nutr     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  552-7     Citation Subset:  IM    
Woolcock Institute of Medical Research, Australia.
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MeSH Terms
Cardiovascular Diseases / blood,  prevention & control
Child Nutritional Physiological Phenomena / physiology
Child, Preschool
Diet Records
Dietary Fats, Unsaturated / administration & dosage,  blood
Dietary Supplements
Fatty Acids, Omega-3 / administration & dosage*,  blood*
Fatty Acids, Omega-6 / administration & dosage*,  blood*
Phospholipids / analysis,  blood
Regression Analysis
Treatment Outcome
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Phospholipids

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