Document Detail


Effect of olmesartan and pravastatin on experimental cerebral aneurysms in rats.
MedLine Citation:
PMID:  20114040     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The major initiation process of intracranial aneurysms is thought to involve endothelial dysfunction due to hemodynamic stress. Angiotensin II type 1 receptor blockers and statins improve vascular endothelium function. The effects of olmesartan and pravastatin were investigated on the development of experimental aneurysms in rats. Eighty-three rats underwent aneurysm induction. Seven groups of 10-14 rats were treated with low or high dose olmesartan, low or high dose pravastatin, low doses of olmesartan and pravastatin, hydralazine, or no drug (control) for 12weeks, when rats were sacrificed for vascular corrosion casting and scanning electron microscopy. Aneurysmal changes at the anterior cerebral-olfactory artery bifurcation were divided into stages 0 (no abnormality) to III (saccular aneurysm). Systolic arterial blood pressure was elevated over 170mmHg in the control, low dose pravastatin, and high dose pravastatin groups, but not in the other groups. The control group demonstrated aneurysmal changes in 100% and stage III in 50% of rats. Aneurysmal changes were observed in most rats in the other groups, but the incidence of stage III was 10% or less. The staging pattern showed significant differences between the groups (P=0.028). Pravastatin reduced both stages III and II+III and olmesartan ameliorated stage III, implying that these may prevent aneurysmal formation through acting on different steps. (209 words).
Authors:
Naoto Kimura; Hiroaki Shimizu; Hany Eldawoody; Toshio Nakayama; Atsushi Saito; Teiji Tominaga; Akira Takahashi
Publication Detail:
Type:  Journal Article     Date:  2010-01-28
Journal Detail:
Title:  Brain research     Volume:  1322     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-12     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  144-52     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Neuroendovascular therapy, Tohoku University Graduate School of Medicine, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II Type 1 Receptor Blockers / pharmacology
Animals
Cerebral Arteries / drug effects*,  pathology,  physiopathology
Circle of Willis / drug effects,  pathology,  physiopathology
Corrosion Casting
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Therapy, Combination
Endothelial Cells / drug effects*,  pathology
Hydralazine / pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology
Imidazoles / pharmacology*
Intracranial Aneurysm / drug therapy*,  pathology,  physiopathology
Microscopy, Electron, Scanning
Pravastatin / pharmacology*
Rats
Tetrazoles / pharmacology*
Treatment Outcome
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Imidazoles; 0/Tetrazoles; 0/Vasodilator Agents; 0/olmesartan; 81093-37-0/Pravastatin; 86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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