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Effect of olive pomace extracts on hyperlipidaemia.
MedLine Citation:
PMID:  21740285     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In this study, we have examined the hypolipidemic effect of olive pomace extracts. Identification and quantitation of maslinic acid and oleanolic acid as the potentially effective components of the pomace extracts were carried out by high performance liquid chromatography methods. Hyperlipidaemia was induced in male Sprague Dawley rats by feeding them with a high cholesterol diet for 30 days. The olive pomace extracts were supplemented (200?mg?kg(?1)?body wt?day(?1)) for 15 days. The levels of serum total cholesterol, triglyceride, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, aspartate aminotransferase and alanine aminotransferase increased in rats with hyperlipidaemia. Treatment with the olive pomace extracts significantly modulated the abnormalities induced by hyperlipidaemia. Lipid accumulation was decreased in histological findings. This study provides the possibility of utilising the olive pomaces for the prevention and treatment of hyperlipidaemia.
Authors:
Jun Liu; Hongbin Sun; Jing Shang; Yuanyuan Yong; Luyong Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Natural product research     Volume:  25     ISSN:  1478-6427     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1190-4     Citation Subset:  IM    
Affiliation:
a National Drug Screening Center, China Pharmaceutical University , 24 Tongjiaxiang , Nanjing 210009 , China.
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