Document Detail


Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer.
MedLine Citation:
PMID:  22459463     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The present study was conducted to formulate and evaluate flurbiprofen transdermal gel. A standard calibration curve was constructed to obtain a regression line equation to be used for finding out the concentration of drug in samples. Olive oil was used as penetration enhancer and was added in different concentrations to some selected formulations to see its enhancement effect on in vitro drug release profiles. The prepared gels were evaluated for several physico-chemical parameters to justify their suitability for topical use. The in vitro drug release studies were carried out by using Franz cell diffusion apparatus across both synthetic membrane and excised albino rabbit skin. In order to investigate the drug release mechanism a kinetic approach was made by employing Korsmeyer kinetic model to the in vitro drug release profiles of flurbiprofen. The flurbiprofen topical gels were successfully prepared and could be beneficial for topical use.
Authors:
Abid Hussain; Gul Majid Khan; Syed Umer Jan; Shefaatullah Shah; Kifayatullah Shah; Muhammad Akhlaq; Nouman Rahim; Asif Nawaz; Abdul Wahab
Related Documents :
13679663 - Retinal vein thrombosis: risk factors, pathogenesis and therapeutic approach.
22344293 - Recombinant protein-based polymers for advanced drug delivery.
7846083 - Formulation and in vitro study of antibacterial vaginal suppositories.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pakistan journal of pharmaceutical sciences     Volume:  25     ISSN:  1011-601X     ISO Abbreviation:  Pak J Pharm Sci     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426356     Medline TA:  Pak J Pharm Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  365-9     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, (KPK), Pakistan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vitro assessment of relief to oxidative stress by different fractions of Boerhavia procumbens.
Next Document:  Development and validation of a stability indicating HPLC method for the analysis of lornoxicam in p...