| Effect of oligofucose derivatives on acetic acid-induced gastric ulcer in rats. | |
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MedLine Citation:
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PMID: 11281579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study attempted to enhance the anti-ulcer activity of fucoidan from Cladosiphon okamuranus TOKIDA by chemical modification with a hydrophobic group. The suitable number of fucose residues in the effective compound was also clarified to obtain a compound of constant quality. Degraded fucoidans were coupled with several hydrophobic groups via Schiff bases, and their anti-ulcer activities were determined by acetic acid-induced ulcer models in rats. Size-fractionated oligofucose was also modified and assayed for anti-ulcer activity. Among the modified oligofucoses, only the oligofucose-dodecylaniline combination (OFDA) significantly promoted ulcer healing. The effective dose was 0.2 mg/kg/d. The most suitable number of fucose residues in the compound for the anti-ulcer activity was determined to be around 12. We succeeded in enhancing the anti-ulcer activity of Cladosiphon fucoidan by modification with dodecylaniline. The activity of this compound was comparable or greater than that of typical anti-ulcer agents. By determination of the optimal OF chain length for the anti-ulcer activity of OFDA, it became possible to obtain OFDA of constant quality. |
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Authors:
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H Shibata; M Nagaoka; I K Takagi; S Hashimoto; R Aiyama; T Yokokura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bio-medical materials and engineering Volume: 11 ISSN: 0959-2989 ISO Abbreviation: Biomed Mater Eng Publication Date: 2001 |
Date Detail:
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Created Date: 2001-04-02 Completed Date: 2001-06-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9104021 Medline TA: Biomed Mater Eng Country: Netherlands |
Other Details:
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Languages: eng Pagination: 55-61 Citation Subset: IM |
Affiliation:
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Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan. hideyuki-shibata@yakult.co.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid Animals Anti-Ulcer Agents / chemistry*, pharmacology, therapeutic use* Disease Models, Animal* Drug Evaluation, Preclinical Male Molecular Weight Polysaccharides / chemistry*, pharmacology, therapeutic use* Rats Rats, Sprague-Dawley Seaweed / chemistry Stomach Ulcer / chemically induced, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Polysaccharides; 64-19-7/Acetic Acid; 9072-19-9/fucoidan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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