| Effect of oleic, lauric and myristic acids on phenylephrine-induced contractions of isolated rat vas deferens. | |
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MedLine Citation:
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PMID: 21941942 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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D-004, a lipid extract of Roystonea regia fruits that contains oleic, lauric and myristic acids as major components inhibits alpha1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens and prostate trips; no study has demonstrated a similar effect for oleic, lauric or myristic acids individually. Therefore, the effects of D-004 (250 microg/mL), oleic (100 microg/mL), lauric (50 microg/mL) or myristic (25 microg/mL) acids and their combined effects on phenylephrine (PHE: 10(-7)-10(-4) mol/L) induced contractions has been studied. No treatment changed the basal tone of the preparations, but all inhibited PHE-induced contractions. D-004 produced the highest inhibition, followed by lauric acid, which was more effective than myristic and oleic acids against PHE-induced contractions of control group. D-004 and the mixture of the three acids produced similar inhibitions. |
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Authors:
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M L Arruzazabala; Y Pérez; Y Ravelo; V Molina; D Carbajal; R Mas; E Rodríguez |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 49 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: India |
Other Details:
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Languages: eng Pagination: 684-8 Citation Subset: IM |
Affiliation:
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Centre of Natural Products, National Centre for Scientific Research 25th Ave, 158 st., P.O 6880, Cubanacáin, Havana City, Cuba. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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