Document Detail


Effect of oleamide on sleep and its relationship to blood pressure, body temperature, and locomotor activity in rats.
MedLine Citation:
PMID:  11681856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oleamide (cis-9,10-octadecenoamide) is a brain lipid that has recently been isolated from the cerebral fluid of sleep-deprived cats. Intracerebroventricular and intraperitoneal administration of oleamide induces sleep in rats. However, it is unclear whether oleamide's hypnogenic effects are mediated, in part, by its actions on blood pressure and core body temperature. Here we show that systemic administration of oleamide (10 and 20 mg/kg) in rats increased slow-wave sleep 2, without affecting blood pressure and heart rate. In addition, oleamide decreased body temperature and locomotor activity in a dose-dependent manner. These latter effects were not correlated in time with the observed increases in slow-wave sleep. These data suggest that the hypnogenic effects of oleamide are not related to changes in blood pressure, heart rate, or body temperature.
Authors:
S Huitrón-Reséndiz; L Gombart; B F Cravatt; S J Henriksen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental neurology     Volume:  172     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-29     Completed Date:  2001-12-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  235-43     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Affiliation:
Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects
Blood Pressure / drug effects*
Body Temperature / drug effects*
Dose-Response Relationship, Drug
Handling (Psychology)
Heart Rate / drug effects
Injections, Intraperitoneal
Injections, Intraventricular
Male
Motor Activity / drug effects*
Oleic Acids / administration & dosage*
Rats
Rats, Sprague-Dawley
Sleep / drug effects*
Grant Support
ID/Acronym/Agency:
DA08301/DA/NIDA NIH HHS; MH58542/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Oleic Acids; 301-02-0/oleylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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