Document Detail

Effect of off-pump coronary artery bypass surgery on clinical, angiographic, neurocognitive, and quality of life outcomes: randomised controlled trial.
MedLine Citation:
PMID:  16740529     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the clinical, angiographic, neurocognitive, and quality of life outcomes of off-pump coronary artery bypass surgery with conventional coronary artery bypass grafting surgery using cardiopulmonary bypass.
DESIGN: Randomised controlled clinical trial.
SETTING: Tertiary cardiothoracic centre in Middlesex, England.
PARTICIPANTS: 168 patients (27 women) requiring primary isolated coronary artery bypass grafting surgery.
INTERVENTIONS: Patients were randomised to conventional coronary artery bypass grafting surgery using cardiopulmonary bypass (n = 84) or off-pump coronary artery bypass surgery (n = 84), carried out by one surgeon. Angiographic examination was carried out at three months postoperatively. Neurocognitive tests were carried out at baseline and at six weeks and six months postoperatively.
MAIN OUTCOME MEASURES: Clinical outcome, graft patency at three months, neurocognitive function at six weeks and six months, and health related quality of life.
RESULTS: Graft patency was evaluated by angiography in 151 (89.9%) patients and was similar between the cardiopulmonary bypass and off-pump groups (risk difference - 1%, 95% confidence interval - 5% to 4%), with the off-pump group considered the treatment group. Patients in the off-pump group required fewer blood transfusions (1.7 units v 1.0 unit, P = 0.02), shorter duration of mechanical ventilation (7.7 hours v 3.9 hours, P = 0.03), and shorter hospital stay (10.8 days v 8.9 days). Scores for neurocognitive function showed a significant difference in three memory subtests at six weeks and two memory subtests at six months in favour of the off-pump group.
CONCLUSIONS: Patients who underwent off-pump coronary artery bypass surgery showed similar patency of grafts, better clinical outcome, shorter hospital stay, and better neurocognitive function than patients who underwent conventional coronary artery bypass grafting surgery using cardiopulmonary bypass.
Sharif Al-Ruzzeh; Shane George; Mahmoud Bustami; Jo Wray; Charles Ilsley; Thanos Athanasiou; Mohamed Amrani
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2006-06-01
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  332     ISSN:  1756-1833     ISO Abbreviation:  BMJ     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-09     Completed Date:  2006-06-14     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  England    
Other Details:
Languages:  eng     Pagination:  1365     Citation Subset:  AIM; IM    
National Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, Harefield Hospital, Middlesex UB9 6JH.
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MeSH Terms
Cognition Disorders / etiology*,  psychology
Coronary Artery Bypass, Off-Pump / adverse effects*
Graft Survival*
Length of Stay
Neuropsychological Tests
Postoperative Complications / etiology*
Quality of Life*
Treatment Outcome
Vascular Patency / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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