Document Detail

Effect of oestrogen and progesterone on noradrenergic nerves and on nerves showing serotonin-like immunoreactivity in the basilar artery of the rabbit.
MedLine Citation:
PMID:  3285957     Owner:  NLM     Status:  MEDLINE    
The effects of oestrogen and progesterone on noradrenergic nerves and nerves with serotonin (5-HT)-like immunoreactivity in the basilar artery were investigated in the rabbit using whole-mount stretch preparations. The noradrenergic nerves were demonstrated by glyoxylic acid fluorescence histochemistry and nerves with 5-HT-like immunoreactivity by indirect immunofluorescence techniques. Quantitative image analysis of fluorescent nerve fibres revealed that nerve density and varicosity diameter of nerves with 5-HT-like immunoreactivity were significantly (P less than 0.01 and P less than 0.05 respectively) reduced after 4-week administration of oestrogen and the intensity of fluorescence was also reduced. However, there were no significant changes after progesterone. Neither oestrogen nor progesterone had any effect on noradrenergic innervation. The findings are discussed in relation to higher incidence of migraine headaches in females taking oral contraceptives.
U Dhall; T Cowen; A J Haven; G Burnstock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  442     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-06-30     Completed Date:  1988-06-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  335-9     Citation Subset:  IM    
Department of Anatomy and Developmental Biology, University College London, U.K.
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MeSH Terms
Adrenergic Fibers / drug effects,  physiology*
Basilar Artery / innervation*
Estradiol / pharmacology*
Fluorescent Antibody Technique
Progesterone / pharmacology*
Reference Values
Serotonin / analysis*,  immunology
Reg. No./Substance:
50-28-2/Estradiol; 50-67-9/Serotonin; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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