Document Detail

Effect on ocular blood flow of Combigan® versus placebo in patients with ocular hypertension.
MedLine Citation:
PMID:  21440829     Owner:  NLM     Status:  Publisher    
PURPOSE: This study was undertaken to compare the ocular haemodynamic effects of Combigan(®) versus placebo in patients with ocular hypertension (OHT). METHODS: Thirty patients with OHT were included in a controlled, randomised, double blind study in two parallel groups; 15 were randomised to receive Combigan(®) and 15 to receive placebo for a period of 3 months. At baseline and at 3 months retrobulbar blood flowmeasurements of the ophthalmic artery (OA) and central retinal artery (CRA) were taken using colour Doppler imaging(CDI) ultrasound, concurrently with intraocular pressure (IOP). RESULTS: Combigan(®) significantly reduced IOP after 3 months of treatment (P = 0.001), whereas placebo showed no significant change in IOP. The baseline haemodynamic parameters were similar between treatment and placebo groups. Patients treated with Combigan® showed a statistically significant decrease in CRA resistive index (P = 0.007). CONCLUSIONS: Patients treated for 3 months with Combigan(®) showed a significant decrease of CRA resistive index that could be explained by the decrease in IOP.
B Puerto-Hernández; G Rebolleda; J L García-Pérez; F J Muñoz-Negrete; C González-Gordaliza
Related Documents :
11497499 - A successful 15-year experience in double-dome tip surgery via endonasal approach: nuan...
21110509 - Intravitreal bevacizumab for myopic choroidal neovascularization: 1-year and 2-year res...
6778629 - Long-term study of flunisolide treatment in perennial rhinitis with special reference t...
19086309 - Middle turbinate preservation versus middle turbinate resection in endoscopic surgical ...
21145269 - Quality of life in patients with small abdominal aortic aneurysm: the effect of early e...
21205409 - Outcomes of cardiac surgery in trisomy 18 patients.
17591009 - Clinical diagnostic criteria for suspected ileocaecal tuberculosis.
21493229 - Use of tutoplast-processed fascia lata as an onlay graft material for tip surgery in rh...
18358379 - Patient-reported activity level after total knee arthroplasty.
Publication Detail:
Journal Detail:
Title:  Archivos de la Sociedad Espanola de Oftalmologia     Volume:  86     ISSN:  1989-7286     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1304603     Medline TA:  Arch Soc Esp Oftalmol     Country:  -    
Other Details:
Languages:  ENG; SPA     Pagination:  42-46     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Espana.
Servicio de Oftalmología, Unidad de Glaucoma, IRYCIS, Hospital Ramón y Cajal, Madrid, España.
Vernacular Title:
Efecto de Combigan(®) versus placebo en el flujo sanguíneo ocular en pacientes hipertensos oculares.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Onlay and inlay bone grafts with platelet-rich plasma: histologic evaluations from human biopsies.
Next Document:  Functional results after endothelial queratoplasty: three years of experience.