Document Detail

Effect on ocular blood flow of Combigan® versus placebo in patients with ocular hypertension.
MedLine Citation:
PMID:  21440829     Owner:  NLM     Status:  Publisher    
PURPOSE: This study was undertaken to compare the ocular haemodynamic effects of Combigan(®) versus placebo in patients with ocular hypertension (OHT). METHODS: Thirty patients with OHT were included in a controlled, randomised, double blind study in two parallel groups; 15 were randomised to receive Combigan(®) and 15 to receive placebo for a period of 3 months. At baseline and at 3 months retrobulbar blood flowmeasurements of the ophthalmic artery (OA) and central retinal artery (CRA) were taken using colour Doppler imaging(CDI) ultrasound, concurrently with intraocular pressure (IOP). RESULTS: Combigan(®) significantly reduced IOP after 3 months of treatment (P = 0.001), whereas placebo showed no significant change in IOP. The baseline haemodynamic parameters were similar between treatment and placebo groups. Patients treated with Combigan® showed a statistically significant decrease in CRA resistive index (P = 0.007). CONCLUSIONS: Patients treated for 3 months with Combigan(®) showed a significant decrease of CRA resistive index that could be explained by the decrease in IOP.
B Puerto-Hernández; G Rebolleda; J L García-Pérez; F J Muñoz-Negrete; C González-Gordaliza
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Publication Detail:
Journal Detail:
Title:  Archivos de la Sociedad Espanola de Oftalmologia     Volume:  86     ISSN:  1989-7286     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1304603     Medline TA:  Arch Soc Esp Oftalmol     Country:  -    
Other Details:
Languages:  ENG; SPA     Pagination:  42-46     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Espana.
Servicio de Oftalmología, Unidad de Glaucoma, IRYCIS, Hospital Ramón y Cajal, Madrid, España.
Vernacular Title:
Efecto de Combigan(®) versus placebo en el flujo sanguíneo ocular en pacientes hipertensos oculares.
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