| Effect on ocular blood flow of Combigan® versus placebo in patients with ocular hypertension. | |
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MedLine Citation:
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PMID: 21440829 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: This study was undertaken to compare the ocular haemodynamic effects of Combigan(®) versus placebo in patients with ocular hypertension (OHT). METHODS: Thirty patients with OHT were included in a controlled, randomised, double blind study in two parallel groups; 15 were randomised to receive Combigan(®) and 15 to receive placebo for a period of 3 months. At baseline and at 3 months retrobulbar blood flowmeasurements of the ophthalmic artery (OA) and central retinal artery (CRA) were taken using colour Doppler imaging(CDI) ultrasound, concurrently with intraocular pressure (IOP). RESULTS: Combigan(®) significantly reduced IOP after 3 months of treatment (P = 0.001), whereas placebo showed no significant change in IOP. The baseline haemodynamic parameters were similar between treatment and placebo groups. Patients treated with Combigan® showed a statistically significant decrease in CRA resistive index (P = 0.007). CONCLUSIONS: Patients treated for 3 months with Combigan(®) showed a significant decrease of CRA resistive index that could be explained by the decrease in IOP. |
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Authors:
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B Puerto-Hernández; G Rebolleda; J L García-Pérez; F J Muñoz-Negrete; C González-Gordaliza |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Archivos de la Sociedad Espanola de Oftalmologia Volume: 86 ISSN: 1989-7286 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-3-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1304603 Medline TA: Arch Soc Esp Oftalmol Country: - |
Other Details:
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Languages: ENG; SPA Pagination: 42-46 Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Espana. |
Affiliation:
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Servicio de Oftalmología, Unidad de Glaucoma, IRYCIS, Hospital Ramón y Cajal, Madrid, España. |
Vernacular Title:
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Efecto de Combigan(®) versus placebo en el flujo sanguíneo ocular en pacientes hipertensos oculares. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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