| Effect of occupational lead-exposure on blood pressure, serum aldosterone level and plasma renin activity. | |
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MedLine Citation:
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PMID: 17219850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous observations have indicated a relationship between lead exposure and elevated blood pressure. The present study aims to investigate the association between occupational lead-exposure and elevated blood pressure as well as serum aldosterone level and plasma renin activity as parameters affecting blood pressure. Fifty occupationally lead-exposed (16 males and 34 females) and 50 non-exposed (15 males and 34 females) workers were selected after application of certain exclusion criteria. All workers were admitted to complete clinical examination, including standard blood pressure measurement. Also, blood lead level, serum aldosterone concentration and plasma renin activity were estimated. The results of both occupationally lead-exposed males and females demonstrated no significant differences regarding age, work duration, systolic and diastolic blood pressures when compared to occupationally non-exposed males and females; respectively. In addition, occupationally lead-exposed males and females revealed a significant increase in blood lead level and serum aldosterone concentration in comparison to their controls. Moreover, plasma renin activity is significantly decreased among the lead-exposed male workers while it is significantly increased among the lead-exposed female workers in comparison to their controls. It is concluded that serum aldosterone level and plasma renin activity are affected by occupationally low-level of lead exposure, and the present study provide further support for the association between blood lead exposure and blood pressure related hormones. |
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Authors:
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A E Shouman; I A El-Safty |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of the Egyptian Public Health Association Volume: 75 ISSN: 0013-2446 ISO Abbreviation: J Egypt Public Health Assoc Publication Date: 2000 |
Date Detail:
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Created Date: 2007-01-15 Completed Date: 2007-02-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505602 Medline TA: J Egypt Public Health Assoc Country: Egypt |
Other Details:
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Languages: eng Pagination: 73-91 Citation Subset: IM |
Affiliation:
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Comm. Occup. Environ. Dept., Faculty of Med., Ain-Shams Univ. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood* Blood Pressure / drug effects* Environmental Pollutants / adverse effects, analysis Female Humans Lead / blood*, toxicity* Male Middle Aged Occupational Diseases / chemically induced* Occupational Exposure / adverse effects*, analysis Renin / blood* |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 52-39-1/Aldosterone; 7439-92-1/Lead; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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