Document Detail


Effect of occupational exposure to rayon manufacturing chemicals on skin barrier to evaporative water loss.
MedLine Citation:
PMID:  15492459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the effects of the occupational exposure to rayon manufacturing chemicals (RMC, containing predominantly carbon disulfide (CS(2)) and minor sulfuric acid) in a rayon factory on the basal transepidermal water loss (TEWL), barrier integrity (BI), and sequential increasing TEWL profiles. Six Thais and five Chinese workers in the spinning department of a rayon manufacturing plant and five healthy unexposed controls were recruited as the test subjects. An area of 4.5 x 5.5 cm on the mid-side of the volar forearm on the right hand was stripped by means of moderate pressure with commercially available adhesive tape by the same technician throughout the experiment. The skin was progressively stripped until glistening. TEWL was measured at every three and five tape strips on the right hand. The corresponding site on the left hand was measured parallel as the self-control. We found significant differences in basal TEWL and in BI between Chinese workers and Chinese controls, and between Thai workers and Chinese workers, respectively. Two-stage patterns of progressive TEWL profiles were found in such a chronic and repeated occupational exposure to RMC containing CS(2). The occupational exposure to RMC could result in the perturbation of the skin barrier function. Basal TEWL might be more sensitive to chronic skin irritant exposure. The TEWL profile achieved to the glistening stage might be necessary to avoid erroneous pattern estimation. Due to the lack of Thais control in this study, the racial difference in response to the RMC warrants further study.
Authors:
Tzu-Chieh Chou; Tung-Sheng Shih; Jui-Chen Tsai; Jyun-De Wu; Hamm-Min Sheu; Ho-Yuan Chang
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of occupational health     Volume:  46     ISSN:  1341-9145     ISO Abbreviation:  J Occup Health     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-19     Completed Date:  2005-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9616320     Medline TA:  J Occup Health     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  410-7     Citation Subset:  IM    
Affiliation:
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbon Disulfide / poisoning
Cellulose / chemistry
Hazardous Substances / poisoning
Humans
Middle Aged
Occupational Exposure*
Skin / chemistry,  drug effects*,  metabolism
Sulfuric Acids / poisoning
Water Loss, Insensible / drug effects*
Chemical
Reg. No./Substance:
0/Hazardous Substances; 0/Sulfuric Acids; 61788-77-0/rayon; 75-15-0/Carbon Disulfide; 7664-93-9/sulfuric acid; 9004-34-6/Cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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