Document Detail

Effect of occlusive wound dressing supplemented with antiphlogistic and analgesic agents on plasma beta-endorphin in hot and humid environments: a study in pigs.
MedLine Citation:
PMID:  12865225     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the changes of plasma beta-endorphin (beta-EP) in pigs with traumatic injury after occlusive wound dressing supplemented with antiphlogistic and analgesic agents in hot and humid environments (HHE). METHODS: Traumatic models were established in 10 pigs, 5 of which received antiphlogistic- and analgesic-supplemented occlusive dressings of the wounds (experiment group, EG), while the rest pigs were assigned to control group (CG) to receive routine wound management. The pigs in both groups were then exposed to artificial HHE and at different time points during the exposure, the plasma beta-EP level, respiratory frequency and heart rates were measured respectively. RESULTS: The plasma beta-EP concentration of EG was significantly lower than that of CG (P <0.01) after the injury, but in both groups, the levels before the injury were similar to those measured at hour 8 during HHE exposure and at hour 24 following the injury. The variation range of the respiratory frequency and heart rates during HHE exposure were significantly smaller in EG than CG (P <0.01). CONCLUSION: This supplemented occlusive wound dressing can help restrain the peak of plasma beta-EP level and the variation range of respiratory frequency and heart rates of pigs exposed to HHE.
Wen-zhi Cai; Ya-jie Li; Bao-ta Cai; Can-hui Zeng; Ying Wang; Bing-de Luo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA     Volume:  23     ISSN:  1000-2588     ISO Abbreviation:  Di Yi Jun Yi Da Xue Xue Bao     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-16     Completed Date:  2004-01-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9426110     Medline TA:  Di Yi Jun Yi Da Xue Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  699-701     Citation Subset:  IM    
Department of Nursing, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
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MeSH Terms
Analgesics / administration & dosage*
Heart Rate
Hot Temperature
Occlusive Dressings*
beta-Endorphin / blood*
Reg. No./Substance:
0/Analgesics; 60617-12-1/beta-Endorphin

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