Document Detail

Effect of obesity on pulmonary function in children.
MedLine Citation:
PMID:  8367219     Owner:  NLM     Status:  MEDLINE    
The effect of obesity on pulmonary function was studied in 13 children, aged 8-15 years, with 147-300% ideal body weight (IBW). Measurements included lung volumes, airflow rates pre- and post-bronchodilator nebulization, diffusing capacity (DLCO), maximal voluntary ventilation (MVV), minute ventilation VE), and resting energy expenditure (REE). When compared with predicted normal values for sex, height, and body surface area (BSA), decreases (mean % predicted, +/- SE) were observed in expiratory reserve volume (ERV, 36 +/- 5); forced expiratory volume in 1 second (FEV1, 73 +/- 5); forced expiratory flow between 25% and 75% of vital capacity (FEF25-75%, 70 +/- 6); DLCO, absolute (52 +/- 3) and corrected (DLCO/VA, 71 +/- 5); and MVV (62 +/- 5). Residual volume (RV), RV/total lung capacity (TLC), VE, and REE were elevated. Other lung volumes were normal. Thus, obese children have altered pulmonary function, which is characterized by reductions in DLCO and ventilatory muscle endurance and airway narrowing. These alterations may reflect extrinsic mechanical compression on the lung and thorax, and/or intrinsic changes within the lung. The reduced DLCO may result from decreases in alveolar surface area relative to lung volume.
L S Inselma; A Milanese; A Deurloo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  16     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-10-06     Completed Date:  1993-10-06     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  130-7     Citation Subset:  IM    
Department of Pediatrics, Newington Children's Hospital, Connecticut.
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MeSH Terms
Energy Metabolism
Lung Volume Measurements
Obesity / physiopathology*
Pulmonary Ventilation
Respiratory Mechanics*
Respiratory Muscles / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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