| Effect of obesity on the plasma lipoprotein subclass profile in normoglycemic and normolipidemic men and women. | |
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MedLine Citation:
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PMID: 18779822 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the effect of obesity without the confounding effect of metabolic complications on the lipoprotein subclass profile in men and women. DESIGN: Cross-sectional study. SUBJECTS: A total of 40 lean (body mass index (BMI): 18.5-25 kg/m(2)) and 40 obese (BMI: 30-45 kg/m(2)) subjects, with blood pressure <140/90 mm Hg, fasting plasma glucose concentration <100 mg per 100 ml and total triglyceride concentration <150 mg per 100 ml; all obese subjects had normal oral glucose tolerance. MEASUREMENTS: Fasting concentrations of very low-, intermediate-, low- and high-density lipoproteins (VLDL, IDL, LDL, and HDL, respectively) and average VLDL, LDL and HDL particle sizes were evaluated by using proton nuclear magnetic resonance spectroscopy. RESULTS: Obese compared with lean individuals of both sexes had increased plasma concentrations of VLDL (by approximately 50%), IDL (by approximately 100%), LDL (by approximately 50%), and to some extent HDL (by approximately 10%) particles (P<0.05). The contribution of large VLDL to total VLDL concentration, small LDL to total LDL concentration, and small HDL to total HDL concentration was greater in obese than lean subjects (P<0.05), resulting in larger average VLDL size but smaller average LDL and HDL sizes (P<0.05). Women, compared with men, had reduced concentrations of total VLDL particles (by approximately 10%) due to lower concentrations of large and medium VLDL and a shift toward large at the expense of small HDL particles (P<0.05), with no difference in total HDL particle concentration. IDL and total LDL concentrations and LDL subclass distribution were not different between men and women. CONCLUSION: Obesity is associated with pro-atherogenic alterations in the lipoprotein subclass profile, which may increase cardiovascular disease risk even in the absence of classical metabolic risk factors. On the other hand, the female cardiovascular disease risk advantage is probably largely related to differences in traditional lipid risk factors (plasma triglyceride and HDL-cholesterol concentrations) because sex differences in the plasma lipoprotein subclass profile are minimal. |
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Authors:
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F Magkos; B S Mohammed; B Mittendorfer |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-09-09 |
Journal Detail:
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Title: International journal of obesity (2005) Volume: 32 ISSN: 1476-5497 ISO Abbreviation: Int J Obes (Lond) Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-17 Completed Date: 2009-07-02 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101256108 Medline TA: Int J Obes (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 1655-64 Citation Subset: IM |
Affiliation:
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Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Blood Glucose / metabolism* Body Mass Index Coronary Artery Disease / blood*, prevention & control Cross-Sectional Studies Female Glucose Tolerance Test Humans Lipoproteins / blood* Magnetic Resonance Spectroscopy Male Middle Aged Obesity / blood* Particle Size Risk Factors Sex Factors Triglycerides / blood Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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AR 49869/AR/NIAMS NIH HHS; DK 56341/DK/NIDDK NIH HHS; HD 057796/HD/NICHD NIH HHS; M01 RR000036-441502/RR/NCRR NIH HHS; P30 DK056341-08/DK/NIDDK NIH HHS; P41 RR000954-27S10255/RR/NCRR NIH HHS; P50 HD057796-01/HD/NICHD NIH HHS; R01 AR049869-01A1/AR/NIAMS NIH HHS; RR 00036/RR/NCRR NIH HHS; UL1 RR024992-01/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Lipoproteins; 0/Triglycerides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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