Document Detail


Effect of obesity and overweight on left ventricular diastolic function: a community-based study in an elderly cohort.
MedLine Citation:
PMID:  21414533     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of this study was to assess the independent effect of increased body size on left ventricular (LV) diastolic function.
BACKGROUND: Obese and overweight persons are at increased risk of heart failure. Left ventricular diastolic dysfunction is an asymptomatic condition associated with future heart failure. It is unclear whether obesity and overweight are independently associated with LV diastolic dysfunction.
METHODS: The LV diastolic function was evaluated in 950 participants from the CABL (Cardiovascular Abnormalities and Brain Lesions) study by traditional and tissue Doppler imaging. Peak early transmitral diastolic flow velocity (E), late transmitral diastolic flow velocity (A), and early diastolic mitral annulus velocity (E') were measured, and E/A and E/E' were calculated. The study sample was divided into 3 groups: normal weight (body mass index [BMI] <25.0 kg/m(2)), overweight (BMI 25.0 to 29.9 kg/m(2)), and obese (BMI ≥30 kg/m(2)).
RESULTS: In multivariate analyses, BMI was independently associated with higher E, A, and E/E', an indicator of LV filling pressure (all p ≤ 0.01). Overweight and obese had lower E' (both p < 0.01) and higher E/E' (both p < 0.01) than normal weight participants. The E/A was lower in obese subjects than in normal weight subjects (p < 0.01). The risk of diastolic dysfunction was significantly higher in overweight subjects (adjusted odds ratio: 1.52, 95% confidence interval: 1.04 to 2.22) and obese subjects (adjusted odds ratio: 1.60, 95% confidence interval: 1.06 to 2.41) compared to normal weight subjects.
CONCLUSIONS: Increased BMI was associated with worse LV diastolic function independent of LV mass and associated risk factors. The increased risk of LV diastolic dysfunction in both overweight and obese persons may partially account for the increased risk of heart failure associated with both conditions.
Authors:
Cesare Russo; Zhezhen Jin; Shunichi Homma; Tatjana Rundek; Mitchell S V Elkind; Ralph L Sacco; Marco R Di Tullio
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  57     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-18     Completed Date:  2011-05-19     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1368-74     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Medicine, Columbia University, New York, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Body Mass Index
Diastole / physiology
Female
Heart Failure / epidemiology,  physiopathology
Humans
Male
Middle Aged
Multivariate Analysis
Obesity / epidemiology,  physiopathology*
Overweight / epidemiology,  physiopathology*
Ventricular Dysfunction, Left / epidemiology*
Grant Support
ID/Acronym/Agency:
R01 NS029993/NS/NINDS NIH HHS; R01 NS029993-10/NS/NINDS NIH HHS; R01 NS036286-10/NS/NINDS NIH HHS; R01 NS36286/NS/NINDS NIH HHS; R37 NS29993/NS/NINDS NIH HHS
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