Document Detail

Effect of obesity and metabolic syndrome on hypoxic vasodilation.
MedLine Citation:
PMID:  21656228     Owner:  NLM     Status:  MEDLINE    
This study was designed to test whether obese adults and adults with metabolic syndrome (MetSyn) exhibit altered hyperemic responses to hypoxia at rest and during forearm exercise when compared with lean controls. We hypothesized blood flow responses due to hypoxia would be lower in young obese subjects (n = 11, 24 ± 2 years, BMI 36 ± 2 kg m(-2)) and subjects with MetSyn (n = 8, 29 ± 3 years BMI 39 ± 2 kg m(-2)) when compared with lean adults (n = 13, 29 ± 2 years, BMI 24 ± 1 kg m(-2)). We measured forearm blood flow (FBF, Doppler Ultrasound) and arterial oxygen saturation (pulse oximetry) during rest and steady-state dynamic forearm exercise (20 contractions/min at 8 and 12 kg) under two conditions: normoxia (0.21 F(i)O(2), ~98% S(a)O(2)) and hypoxia (~0.10 F(i)O(2), 80% S(a)O(2)). Forearm vascular conductance (FVC) was calculated as FBF/mean arterial blood pressure. At rest, the percent change in FVC with hypoxia was greater in adults with MetSyn when compared with lean controls (p = 0.02); obese and lean adult responses were not statistically different. Exercise increased FVC from resting levels in all groups (p < 0.05). Hypoxia caused an additional increase in FVC (p < 0.05) that was not different between groups; responses to hypoxia were heterogeneous within and between groups. Reporting FVC responses as absolute or percent changes led to similar conclusions. These results suggest adults with MetSyn exhibit enhanced hypoxic vasodilation at rest. However, hypoxic responses during exercise in obese adults and adults with MetSyn were not statistically different when compared with lean adults. Individual hypoxic vasodilatory responses were variable, suggesting diversity in vascular control.
Jacqueline K Limberg; Trent D Evans; Gregory M Blain; David F Pegelow; Jessica R Danielson; Marlowe W Eldridge; Lester T Proctor; Joshua J Sebranek; William G Schrage
Related Documents :
21951278 - Effect of orofacial exercises on oral aperture in adults with systemic sclerosis.
21563028 - A 'new' method to normalise exercise intensity.
18053188 - International physical activity questionnaire (ipaq) and new zealand physical activity ...
21799138 - Effects of an interactive computer game exercise regimen on balance impairment in frail...
15839348 - Dosimetric effect of collimating jaws for small multileaf collimated fields.
18509348 - The prognostic value of haemodynamic parameters in the recovery phase of an exercise te...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-09
Journal Detail:
Title:  European journal of applied physiology     Volume:  112     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-05-21     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  699-709     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / complications,  physiopathology*
Blood Flow Velocity
Brachial Artery / physiopathology*
Metabolic Syndrome X / complications,  physiopathology*
Obesity / complications,  physiopathology*
Young Adult
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fluid balance, thermal stress, and post exercise response in women's Islamic athletic clothing.
Next Document:  No case of exercise-associated hyponatraemia in top male ultra-endurance cyclists: the 'Swiss Cyclin...