| Effect of an o-raffinose cross-linked haemoglobin product on oesophageal and lower oesophageal sphincter motor function. | |
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MedLine Citation:
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PMID: 10583849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present experiments evaluate the effects on oesophageal motility of an o-raffinose cross-linked haemoglobin-based oxygen carrier (HBOC) purified from outdated donated human blood cells (HemolinkTM), with attention to dose-response (0.6-2.4 g kg-1), oxygenation status and low molecular weight components (4.4-36.4% 64 kDa or less). In ketamine-anaesthetized cats, lower oesophageal sphincter (LES) function and oesophageal peristalsis were monitored 0.5 h before, during and up to 3.5 h after HBOC infusion, and in some cats at 24 h. (1) All products significantly inhibited LES relaxation and increased peristaltic velocity in the distal smooth muscle oesophagus, without consistently altering resting LES pressure. (2) Effects on peristaltic velocity reached a maximum at the smallest dose, whereas the effects on LES relaxation had a maximum effect at 1.2 g kg-1. (3) Effects were not significantly altered by the haemoglobin oxygenation status or presence of low molecular weight components. (4) Repetitive oesophageal contractions occurred. In the cat, an o-raffinose cross-linked human haemoglobin product produces changes in oesophageal body and LES function, which are independent of the HBOC oxygenation status and composition of the low molecular weight components tested. Changes may persist for at least 24 h. These motility changes are likely due to scavenging of nitric oxide by the haemoglobin. |
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Authors:
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S Xue; W Paterson; D Valdez; D Miller; B Christoff; L T Wong; N E Diamant |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 11 ISSN: 1350-1925 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-01-28 Completed Date: 2000-01-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 421-30 Citation Subset: IM |
Affiliation:
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University of Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Cats Cross-Linking Reagents Dose-Response Relationship, Drug Esophagogastric Junction / drug effects* Esophagus / drug effects* Female Hemoglobins / pharmacology* Male Muscarinic Antagonists / pharmacology Muscle Contraction / drug effects Muscle Relaxation / drug effects Muscle, Smooth / drug effects Oxygen Consumption / drug effects Peristalsis / drug effects Raffinose / analogs & derivatives*, pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cross-Linking Reagents; 0/Hemoglobins; 0/Muscarinic Antagonists; 0/O-raffinose cross-linked human hemoglobin; 51-55-8/Atropine; 512-69-6/Raffinose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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