Document Detail

Effect of nutritive and tonic crude drugs on physical fatigue-induced stress models in mice.
MedLine Citation:
PMID:  12591014     Owner:  NLM     Status:  MEDLINE    
The present study was undertaken to investigate the acute anti-fatigue effect of a liquid nutritive and tonic crude drugs (NTDs) on stress induced in mice. After forced walking for 3 or 6h, the NTDs (applied orally, 10 ml/kg) significantly increased locomotor activity, while the administration of NTDs after rapid eye movement (REM) sleep deprivation stress and after immobilization stress did not show a specific effect, having a similar effect as the vehicle with added vitamins, taurine and caffeine. The administration of NTDs after freezing due to electric shock stress showed a specific effect which was not seen in other control groups, water, vehicle (ethanol) and vehicle including vitamins, taurine and caffeine and so resemble the specific effect of NTDs in the stress of forced walking. The present results indicate that the NTDs produced an anti-fatigue effect on the decreased locomotor activity after forced walking and immobility induced by electric stimulation. However, the crude drugs were not effective in improving immobility after sleep deprivation or immobilization stress.
Takeshi Tadano; Osamu Nakagawasai; Fukie Niijima; Koichi Tan-no; Masa-aki Hanawa; Yasuko Sakata; Den'etsu Sutoo; Yukio Nemoto; Yoshiteru Ida; Yasuo Endo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  47     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-19     Completed Date:  2004-05-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  195-9     Citation Subset:  IM    
Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
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MeSH Terms
Behavior, Animal / drug effects,  physiology
Disease Models, Animal
Drugs, Chinese Herbal / administration & dosage*
Fatigue / drug therapy*,  etiology
Mice, Inbred Strains
Physical Conditioning, Animal / physiology
Sleep Deprivation
Stress, Physiological / drug therapy*,  etiology
Time Factors
Walking / physiology
Reg. No./Substance:
0/Drugs, Chinese Herbal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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