Document Detail


Effect of nutritional status and fat reserves on the periparturient immune response to Haemonchus contortus infection in sheep.
MedLine Citation:
PMID:  16737779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A study was made of the effect of body fat stored by ewes in early pregnancy on the subsequent immune response to gastrointestinal parasites around parturition. Pregnant ewes were given access to a lucerne pelleted diet either ad libitum (H) or at approximately 0.70 of their maintenance requirements (L) from the 42nd day of pregnancy in order to achieve a clearly differentiated level of body reserves by the 90th day of pregnancy. Then, all animals were put on the same plane of nutrition till 3 weeks after parturition. All ewes in both groups received 7,000 infective larvae of Haemonchus contortus per week for 7 weeks prior to lambing. The dietary treatments led to large differences between both groups of ewes in back-fat thickness that had a high correlation with mean plasma concentrations of leptin. In spite of the fact that animals were on the same plane of nutrition at infection time, host resistance, as measured by faecal egg counts, was significantly affected by the nutritional treatment established during early pregnancy. This effect produced noticeable differences in worm size and in worm burden at lambing. The response was accompanied by a marked increase in circulating eosinophils in better-fed ewes than in those maintained on a restricted diet in early pregnancy. Serum pepsinogen concentration, however, was inversely affected by the nutritional treatment till lambing, showing a maximum difference as early as 2 weeks after infection. The results support the view that higher levels of nutrition during early pregnancy enhance the expression of immunity against gastrointestinal parasites around parturition. Furthermore, the differences in the immune response appeared associated with serum leptin levels suggesting that leptin may be a key link between nutritional status and the protective immune reactivity against GI nematode infection.
Authors:
J Valderrábano; C Gomez-Rincón; J Uriarte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-05
Journal Detail:
Title:  Veterinary parasitology     Volume:  141     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-18     Completed Date:  2006-11-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  122-31     Citation Subset:  IM    
Affiliation:
Centro de Investigación y Tecnología Agroalimentaria de Aragón, Zaragoza, Spain. jvalderrabano@aragob.es
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism,  physiology*
Animals
Body Weight / physiology
Energy Intake / immunology
Feces / parasitology
Female
Haemonchiasis / immunology,  parasitology,  veterinary*
Haemonchus / pathogenicity*
Immunity, Innate*
Leptin / blood
Nutritional Status* / immunology,  physiology
Parasite Egg Count / veterinary
Parturition
Pepsinogens / blood
Pregnancy
Random Allocation
Sheep
Sheep Diseases / immunology*,  parasitology
Chemical
Reg. No./Substance:
0/Leptin; 0/Pepsinogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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