| Effect of noradrenaline on tail arteries of SHR and WKY under perfusion at constant flow and constant pressure. | |
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MedLine Citation:
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PMID: 9381948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vasoconstrictor effects of noradrenaline were compared in 6- to 7-month-old spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. A cylindrical segment was dissected from the proximal part of tail artery, cannulated at both ends and perfused alternately either at constant flow or constant pressure. Two series of experiments were performed. In the first series, vessels were perfused/superfused with Krebs-Henseleit solution. In the second one a modified salt solution was used, in which NaCl was totally replaced by an equimolar amount of KCI. Under constant flow conditions noradrenaline evoked a more prominent resistance increase in SHR compared with WKY independently of the composition of solution (normal or high-K+) used. At constant pressure perfusion with normal solution, the vasoconstrictor response to noradrenaline was more prominent in WKY. Under application of high-K+ solution, vasoconstriction at constant pressure in SHR became more pronounced than that in WKY. We suggest that there is greater wall thickness:lumen diameter ratio in SHR vessels and thus different contribution of distension-activated myogenic response is of primary importance for the data obtained. |
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Authors:
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V V Machkov; O S Tarasova; E N Timin; I M Rodionov |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 161 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-11-07 Completed Date: 1997-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 41-6 Citation Subset: IM |
Affiliation:
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Department of Human and Animal Physiology, Biological Faculty, M.V. Lomonosov Moscow State University, Russia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / drug effects Calcium / metabolism Calcium Channels / physiology Hypertension / chemically induced Male Muscle Contraction / drug effects Muscle, Skeletal / blood supply, chemistry, physiology Norepinephrine / pharmacology* Perfusion Rats Rats, Inbred SHR Rats, Inbred WKY Regional Blood Flow / drug effects Tail / blood supply* Vasoconstrictor Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels; 0/Vasoconstrictor Agents; 51-41-2/Norepinephrine; 7440-70-2/Calcium |
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