Document Detail

Effect of noradrenaline on tail arteries of SHR and WKY under perfusion at constant flow and constant pressure.
MedLine Citation:
PMID:  9381948     Owner:  NLM     Status:  MEDLINE    
Vasoconstrictor effects of noradrenaline were compared in 6- to 7-month-old spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. A cylindrical segment was dissected from the proximal part of tail artery, cannulated at both ends and perfused alternately either at constant flow or constant pressure. Two series of experiments were performed. In the first series, vessels were perfused/superfused with Krebs-Henseleit solution. In the second one a modified salt solution was used, in which NaCl was totally replaced by an equimolar amount of KCI. Under constant flow conditions noradrenaline evoked a more prominent resistance increase in SHR compared with WKY independently of the composition of solution (normal or high-K+) used. At constant pressure perfusion with normal solution, the vasoconstrictor response to noradrenaline was more prominent in WKY. Under application of high-K+ solution, vasoconstriction at constant pressure in SHR became more pronounced than that in WKY. We suggest that there is greater wall thickness:lumen diameter ratio in SHR vessels and thus different contribution of distension-activated myogenic response is of primary importance for the data obtained.
V V Machkov; O S Tarasova; E N Timin; I M Rodionov
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  161     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-07     Completed Date:  1997-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Department of Human and Animal Physiology, Biological Faculty, M.V. Lomonosov Moscow State University, Russia.
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MeSH Terms
Arteries / drug effects
Calcium / metabolism
Calcium Channels / physiology
Hypertension / chemically induced
Muscle Contraction / drug effects
Muscle, Skeletal / blood supply,  chemistry,  physiology
Norepinephrine / pharmacology*
Rats, Inbred SHR
Rats, Inbred WKY
Regional Blood Flow / drug effects
Tail / blood supply*
Vasoconstrictor Agents / pharmacology*
Reg. No./Substance:
0/Calcium Channels; 0/Vasoconstrictor Agents; 51-41-2/Norepinephrine; 7440-70-2/Calcium

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