Document Detail

Effect of noradrenaline, bretylium and cocaine on the blood pressure response to tyramine in the rat.
MedLine Citation:
PMID:  13761139     Owner:  NLM     Status:  MEDLINE    
Tyramine is mainly a pressor agent in the rat under urethane, although the hypertensive effect of tyramine in some experiments is followed by a prolonged increase or depression of blood pressure. Bretylium, in doses up to 10 mg/kg, prolonged the response to tyramine, whereas larger doses depressed or blocked its effect. When the hypertensive effect of tyramine was blocked by bretylium, both noradrenaline and dihydroxyphenylalanine, when slowly infused, were found to restore it. The well-known block by cocaine of the hypertensive response to tyramine could also be reversed by intravenous infusion of noradrenaline and dihydroxyphenylalanine. It is concluded that the infusion of noradrenaline and dihydroxyphenylalanine makes available noradrenaline in the postganglionic adrenergic nerves which is necessary for the action of tyramine.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology and chemotherapy     Volume:  16     ISSN:  0366-0826     ISO Abbreviation:  Br J Pharmacol Chemother     Publication Date:  1961 Jun 
Date Detail:
Created Date:  1961-12-01     Completed Date:  1998-11-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0154627     Medline TA:  Br J Pharmacol Chemother     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  320-6     Citation Subset:  OM    
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MeSH Terms
Antihypertensive Agents / pharmacology*
Blood Pressure / pharmacology*
Cocaine / pharmacology*
Norepinephrine / pharmacology*
Tyramine / pharmacology*
Reg. No./Substance:
0/Antihypertensive Agents; 50-36-2/Cocaine; 51-41-2/Norepinephrine; 51-67-2/Tyramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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